198546-38-2

Usage

Uses

Used in Pharmaceutical Industry:
FMOC-2,3-DEHYDRO-VAL-OH is used as a building block for the preparation of peptidomimetics and peptide-based drugs. Its role in the development of new drug candidates is significant, as it contributes to the creation of innovative treatments and therapies.
Used in Academic Research:
In academic research, FMOC-2,3-DEHYDRO-VAL-OH serves as a useful tool for studying protein-protein interactions and structure-activity relationships. This helps scientists better understand the mechanisms of diseases and the behavior of potential drug molecules, thereby aiding in the advancement of medical knowledge.
Used in Organic Synthesis:
FMOC-2,3-DEHYDRO-VAL-OH is also utilized in organic synthesis, where it plays a crucial role in the formation of complex organic molecules. Its unique properties allow it to be a key component in the synthesis of various organic compounds.
Used in Solid-Phase Peptide Synthesis:
Due to its stability and compatibility with standard peptide coupling chemistry, FMOC-2,3-DEHYDRO-VAL-OH is widely used in solid-phase peptide synthesis. This technique is essential for the efficient and controlled assembly of peptide chains, which are vital in the development of peptide drugs and understanding peptide functions.

Upstream product

• 759-05-7 3-methyl-2-ketobutanoic acid 
• 84418-43-9 9-fluorenylmethyl carbamate 
• 55478-14-3 methyl N-(t-butyloxocarbonyl)dehydrovalinate 
• 87746-81-4 C₅H₉NO₂ 
• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 

Relevant academic research and scientific papers

Synthesis method of 2-(9H-fluorene-9-methoxycarbonylamino)-3-methyl-2-butenoic acid

The invention relates to a synthesis method of 2-(9H-fluorene-9-methoxycarbonylamino)-3-methyl-2-butenoic acid. The method mainly solves the technical problem of lack of an amplified production methodof 2-(9H-fluorene-9-methoxycarbonylamino)-3-methyl-2-butenoic acid at present. The synthesis method comprises the following steps: in methyl tert-butyl ether cooled in an ice bath, acidifying 3-methyl-2-oxobutyrate with concentrated hydrochloric acid to generate a compound 1; in methylbenzene subjected to heating reflux, the compound 1 and fluorenylmethoxycarbonylamide are subjected to dehydration condensation reaction under the catalytic action of p-toluenesulfonic acid to generate a target compound 2. As a medical intermediate and a dehydroamino acid derivative, 2-(9H-fluorene-9-methoxycarbonylamino)-3-methyl-2-butenoic acid is widely applied to the fields of synthesis of peptide active substances and protein engineering.

Method for synthesizing fluorenylmethoxycarbonyl-2,3-dehydrovaline

The invention relates to a method for synthesizing fluorenylmethoxycarbonyl-2,3-dehydrovaline. The method mainly solves the technical problem of lack of effective synthesis methods. The synthesis method includes the following steps: reacting Boc-alpha-phosphonomethylglycine trimethyl ester with acetone in a dichloromethane solution under the catalysis of DBU through an HWE to generate a compound 1; heating and hydrolyzing the compound 1 and sodium hydroxide in a mixed solution of methanol and water to generate a compound 2; removing, by the compound 2, a protecting group in the dichloromethanesolution of trifluoroacetic acid to generate a compound 3; and reacting the compound 3, 9-fluorenylmethyl-N-succinimidyl carbonate with sodium bicarbonate in a mixed solution of tetrahydrofuran and water to generate a target compound 4. The fluorenylmethoxycarbonyl-2,3-dehydrovaline, as an amino acid derivative, is mainly used as a pharmaceutical intermediate and in the synthesis of polypeptidesand the like.