198546-38-2 Usage
General Description
FMOC-2,3-DEHYDRO-VAL-OH is a chemical compound with the molecular formula C20H17NO4. It is a derivative of the amino acid valine, with a 2,3-dehydro substitution and a FMOC (9-fluorenylmethoxycarbonyl) protective group. FMOC-2,3-DEHYDRO-VAL-OH is commonly used in organic synthesis and peptide chemistry as a building block for the preparation of peptidomimetics and peptide-based drugs. It is also a useful tool in solid-phase peptide synthesis due to its stability and compatibility with standard peptide coupling chemistry. FMOC-2,3-DEHYDRO-VAL-OH is widely used in the pharmaceutical industry for the development of new drug candidates and in academic research for the study of protein-protein interactions and structure-activity relationships.
Check Digit Verification of cas no
The CAS Registry Mumber 198546-38-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,8,5,4 and 6 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 198546-38:
(8*1)+(7*9)+(6*8)+(5*5)+(4*4)+(3*6)+(2*3)+(1*8)=192
192 % 10 = 2
So 198546-38-2 is a valid CAS Registry Number.
198546-38-2Relevant articles and documents
Synthesis method of 2-(9H-fluorene-9-methoxycarbonylamino)-3-methyl-2-butenoic acid
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Paragraph 0006; 0010, (2020/12/30)
The invention relates to a synthesis method of 2-(9H-fluorene-9-methoxycarbonylamino)-3-methyl-2-butenoic acid. The method mainly solves the technical problem of lack of an amplified production methodof 2-(9H-fluorene-9-methoxycarbonylamino)-3-methyl-2-butenoic acid at present. The synthesis method comprises the following steps: in methyl tert-butyl ether cooled in an ice bath, acidifying 3-methyl-2-oxobutyrate with concentrated hydrochloric acid to generate a compound 1; in methylbenzene subjected to heating reflux, the compound 1 and fluorenylmethoxycarbonylamide are subjected to dehydration condensation reaction under the catalytic action of p-toluenesulfonic acid to generate a target compound 2. As a medical intermediate and a dehydroamino acid derivative, 2-(9H-fluorene-9-methoxycarbonylamino)-3-methyl-2-butenoic acid is widely applied to the fields of synthesis of peptide active substances and protein engineering.
