198554-72-2

Upstream product

• 198551-04-1 4-(4-methoxybenzyl)-6-[1-(phenylcarbonyl)piperidin-4-yl]pyrimidin-2-amine 
• 5274-99-7 1-benzoylisonipecotic acid 
• 115755-50-5 1-benzoyl-4-piperidinecarbonyl chloride 
• 198554-58-4 4-(4-methoxyphenyl)-1-[1-(phenylcarbonyl)piperidin-4-yl]butane-1,3-dione 

Downstream Products

• 198553-25-2 4-[1-(1,3-benzodioxol-5-ylcarbonyl)piperidin-4-yl]-6-(4-methoxybenzyl)pyrimidin-2-amine 
• 198554-80-2 2-Amino-4-[1-(3,4-dibenzyloxybenzoyl)-4-piperidinyl]-6-(4-methoxyphenylmethyl) pyrimidine 
• 198554-21-1 4-[1-(1,3-benzoxazol-6-ylcarbonyl)piperidin-4-yl]-6-(4-methoxybenzyl)pyrimidin-2-amine 
• 198554-06-2 4-[1-(1H-indol-5-ylcarbonyl)piperidin-4-yl]-6-(4-methoxybenzyl)pyrimidin-2-amine 

Relevant academic research and scientific papers

Novel piperidinylpyrimidine derivatives as inhibitors of HIV-1 LTR activation

Piperidinylpyrimidine derivatives, previously prepared as inhibitors of TNF-α production, were evaluated for their inhibitory activity against HIV-1 LTR activation. Some of these derivatives inhibited activation of HIV-1 LTR-directed CAT gene expression i

Synthesis and bioactivities of novel piperidylpyrimidine derivatives: Inhibitors of tumor necrosis factor-alpha production

New piperidylpyrimidine derivatives, including quinazolines, were prepared, and their abilities to inhibit TNF-α production evaluated. Some compounds showed potent inhibitory activity in mouse macrophages stimulated with LPS. The synthesis and structure-activity relationships of these compounds are described. (C) 2000 Elsevier Science Ltd. All rights reserved.

Piperidinylpyrimidine derivatives

A compound of formula (1) STR1 wherein X1 is amino or hydroxyl, X2 is carbonyl and the like R1 is an alkyl, an aryl and the like, R2 is hydrogen and the like, and R3 is an alkyl and the like, or a pharmaceutical acceptable salt thereof is effective for inibiting the production and/or secretion of tumor necrosis factor in a patient in need of such inhibition.