198635-22-2

Upstream product

• 111060-49-2 N,N-dibenzyl-L-alanine benzyl ester 
• 756-79-6 dimethyl methane phosphonate 

Downstream Products

• 198635-26-6 (E)-(S)-4-Dibenzylamino-1-(4-trifluoromethyl-phenyl)-pent-1-en-3-one 
• 198635-27-7 (E)-(S)-4-Dibenzylamino-1-(3-nitro-phenyl)-pent-1-en-3-one 
• 198635-25-5 (E)-(S)-4-Dibenzylamino-1-phenyl-pent-1-en-3-one 

Relevant academic research and scientific papers

Diastereoselective reduction of β-ketophosphonates derived from amino acids. A new entry to enantiopure β-hydroxy-γ-aminophosphonate derivatives

The reduction of γ-N,N-dibenzylamino-β-ketophosphonates 4 derived from readily available (S)-tribenzylated amino acids was achieved with catecholborane at -20°C affording γ-amino-β-hydroxyphosphonates 5 in high diastereoselectivity and good chemical yield. These reactions provide a new entry to enantiomerically pure γ-amino-β-hydroxyphosphonates.

Stereoselective synthesis of β-amino alcohols: Diastereoselective reduction of chiral α-amino enones derived from amino acids

α-Amino acids are doubly benzylated at nitrogen to give N,N-dibenzyl amino acids, which can readily be converted to α'-amino enones 3. The α'-amino enones are very resistant to racemization, and undergo highly diastereoselective reduction to afford chiral amino alcohols upon treatment with L-Selectride under non-chelation control.