1987-40-2

Upstream product

• 13276-30-7 D-ribo-2-Benzamido-1.3.4-trihydroxyoctadec-8-in 
• 13276-35-2 N-((3R,4S,5R)-2,4-Dihydroxy-5-tetradec-4-ynyl-tetrahydro-furan-3-yl)-benzamide 
• 13276-34-1 N-((2R,3R,4S,5R)-4-Hydroxy-2-methoxy-5-tetradec-4-ynyl-tetrahydro-furan-3-yl)-benzamide 
• 13266-04-1 N-((2R,3R,4S,5R)-4-Hydroxy-2-methoxy-5-tetradecyl-tetrahydro-furan-3-yl)-benzamide 
• 13276-29-4 N-((3R,4S,5R)-2,4-Dihydroxy-5-tetradecyl-tetrahydro-furan-3-yl)-benzamide 
• 554-62-1 D-ribo-phytosphingosine 
• 98-88-4 benzoyl chloride 

Downstream Products

• 572922-31-7 (2S,3R,4R)-2-(N-benzoyl)amino-1-O-trityl-octadecane-1,3,4-triol 
• 572922-35-1 2-phenyl-4-(S)-[(1R,2R)-1,2-dihydroxyhexadecyl]-1,3-oxazoline 
• 572922-36-2 1-[4-(S)-(2-Phenyl-4,5-dihydro-oxazol-4-yl)]-(1 S,2R)-1-hydroxy-2-O-mesyl-hexadecane 
• 572922-34-0 2-phenyl-4-(S)-[(1R,2R)-1,2-di(benzoyloxy)hexadecyl]-1,3-oxazoline 
• 572922-33-9 (2S,3R,4R)-2-(N-benzoyl)amino-3,4-di-O-benzoyl-octadecane-1,3,4-triol 
• 572922-32-8 (2S,3R,4R)-2-(N-benzoyl)amino-3,4-di-O-benzoyl-1-O-trityl-octadecane-1,3,4-triol 

Relevant academic research and scientific papers

Effective, high-yielding, and stereospecific total synthesis of D-erythro-(2R,3S)-sphingosine from D-ribo-(2S,3S,4R)-phytosphingosine

The synthesis of naturally occurring D-erythro-(2R,3S,4E)-sphingosine from commercially available D-ribo-(2S,3S,4R)-phytosphingosine is described. The key step in the reaction sequence comprises TMSI/DBN promoted regio- and stereoselective oxirane opening of intermediate 2-phenyl-4-(S)-[(1S,2S)-1,2- epoxyhexadecyl]-1,3-oxazoline followed by the in situ trans-elimination of 2-phenyl-4-(S)-[(1S,2R)-1,2-dideoxy-2-iodo-1-trimethylsilyloxyhexadecyl]-1, 3-oxazoline.

A process for the synthesis of sphingosine

This invention relates to a method for the production of a sphingoid base according to formula comprising the steps of(1) dissolving a starting compound according to formula III or a salt thereof in a substantially inert solvent,(2) protecting the NH2 group with a NH2 protecting group,(3) activating C4 HR3' for an elimination reaction with C5HR4,(4) causing an elimination reaction to take place to form a double bond between the C4 and C5 carbon atom,(5) removing the NH2 protecting group.

Process for the synthesis of sphingosine

This invention relates to a method for the production of a sphingoid base according to formula comprising the steps of (1) dissolving a starting compound according to formula III or a salt thereof in a substantially inert solvent, (2) protecting the NHsu

The synthesis and biological characterization of a ceramide library

A facile synthesis of a combinatorial ceramide library and their activities in the NF-κB pathway and in apoptosis induction/prevention were demonstrated. A novel NF-κB activating molecule was discovered among ceramide containing β-galactose, and the structural requirements of ceramides for apoptosis induction was elucidated. Copyright