198700-45-7

Upstream product

• 39684-80-5 2-(tert-butoxycarbonylamino)ethyl bromide 
• 13036-02-7 Dimethyl 5-hydroxyisophthalate 
• 26690-80-2 2-(N-tert-butoxycarbonylamino)ethanol 
• 198700-42-4 5-(2-phthalimidoethoxy)-isophthalic acid dimethyl ester 

Downstream Products

• 198700-44-6 5-((-2-((tert-butyloxy)carbonyl)amino)ethoxy)benzene-1,3-dicarboxylic acid 
• 215162-41-7 C₆₃H₇₅F₂N₇O₁₃ 

Relevant academic research and scientific papers

NUCLEIC ACID CONJUGATE

The present invention provides a nucleic acid conjugate in which a sugar chain ligand is bonded to an oligonucleotide via a linker, the sugar chain ligand having O-bonded mannose at its non-reducing end.

Facially amphiphilic polymers and oligomers and uses thereof

The present invention discloses methods of use of facially amphiphilic polymers and oligomers, including pharmaceutical uses of the polymers and oligomers as antimicrobial agents and antidotes for hemorrhagic complications associated with heparin therapy.

Higher order iminodiacetic acid libraries for probing protein-protein interactions

Full details of the preparation of iminodiacetic acid diamide dimer (2040 compounds), trimer (560 compounds), and tetramer (1596 compounds) libraries by multistep convergent solution-phase synthesis for studying protein-protein interactions are provided. The libraries were assembled in a format providing small 8-10 compound mixtures and the deconvolution of many of the small mixtures to identify screening leads by resynthesis of the individual components have been conducted for 320 of the individual compounds to date. A representative example of the subsequent exploration of the structure-activity relationships for an identified receptor binding antagonist (200 additional individual compounds) and steps taken for potential elaboration to a receptor dimerization agonist are defined with preparation of representative linked dimers (70 compounds). Copyright (C) 1998 Elsevier Science Ltd.

Perfectly branched polyamide dendrons based on 5-(2-aminoethoxy)- isophthalic acid

Perfectly branched polyamide dendrons based on 5-(2-aminoethoxy)- isophthalic acid have been synthesized up to generation 4 following the convergent approach. This involved a repetitive reaction of 5-(2-t- butoxycarbamylethoxy)-isophthalic acid with the two fold excess of 5-(2- aminoethoxy-hydrochloride)-isophthalic acid dimethyl ester and its analogs of higher generation, respectively, using activation and protection methods from the peptide chemistry. The products were characterized via elemental analysis, different spectroscopic methods, gel permeation chromatograpy, and differential scanning calorimetry.