21858-17-3

Basic information

• Product Name: (R)-7-(benzyloxy)-6-methoxy-1-(4-methoxybenzyl)-2-methyl-1,2,3,4-tetrahydroisoquinoline
• Synonyms: (R)-7-(benzyloxy)-6-methoxy-1-(4-methoxybenzyl)-2-methyl-1,2,3,4-tetrahydroisoquinoline
• CAS NO: 21858-17-3
• Molecular Weight: 403.521
• Mol File: 21858-17-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R)-7-(benzyloxy)-6-methoxy-1-(4-methoxybenzyl)-2-methyl-1,2,3,4-tetrahydroisoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-7-(benzyloxy)-6-methoxy-1-(4-methoxybenzyl)-2-methyl-1,2,3,4-tetrahydroisoquinoline(21858-17-3)
• EPA Substance Registry System: (R)-7-(benzyloxy)-6-methoxy-1-(4-methoxybenzyl)-2-methyl-1,2,3,4-tetrahydroisoquinoline(21858-17-3)

Safety Data

• Hazardous Substances Data: 21858-17-3(Hazardous Substances Data)

Upstream product

• 1135-23-5 3-(4-hydroxy-3-methoxyphenyl)propionic acid 
• 1135-24-6 (E)-3-(4-hydroxy-3-methoxyphenyl)acrylic acid 
• 101565-19-9 (E/Z)-1-methoxy-4-(2-methoxyvinyl)benzene 
• 30034-49-2 β-(4-benzyloxy-3-methoxyphenyl)propionic acid 
• 116185-11-6 benzyl 3-[4-(benzyloxy)-3-methoxyphenyl]propanoate 
• 15357-95-6 7-(benzyloxy)-6-methoxy-1,2,3,4-tetrahydroisoquinoline 
• 50-00-0 formaldehyd 

Downstream Products

• 19879-50-6 (R)-6-methoxy-1-(4-methoxybenzyl)-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-ol 
• 1438250-78-2 (S)-1-(4-(benzyloxy)-3-((R)-6-methoxy-1-(4-methoxybenzyl)-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yloxy)benzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline 
• 2292-16-2 1'-epi-neferine 

Relevant articles and documents

Asymmetric synthesis of O-methylneferine

Diastereoselective Pictet-Spengler reaction of 2-arylethylamine bearing an N-(R)-1-(1-naphthyl)ethylcarbamoyl group with arylacetaldehyde gave 1-benzyltetrahydroisoquinoline in good yield with moderate diastereoselectivity. The reaction was applied to asymmetric synthesis of O-methyl derivative of neferine, an alkaloid of the lotus embryo, Nelumbo nucifera Gaertner.