32559-18-5

Basic information

• Product Name: METHYL PIPECOLINATE HYDROCHLORIDE
• Synonyms: METHYL PIPERIDINE-2-CARBOXYLATE HYDROCHLORIDE;METHYL PIPECOLINATE HCL;METHYL PIPECOLINATE HYDROCHLORIDE;TIMTEC-BB SBB003755;METHY PIPECOLINATE HCL;MethyPipecolinateHydrochloride;N-methyl pipecolinate hydrochloride;Methyl 2-piperidinecarboxylate hydrochloride
• CAS NO: 32559-18-5
• Molecular Formula: C₇H₁₃NO₂*ClH
• Molecular Weight: 179.64
• EINECS: 203-105-6
• Product Categories: Building Blocks;Heterocyclic Building Blocks;Piperidines
• Mol File: 32559-18-5.mol
• Article Data: 17

Chemical Properties

• Melting Point: 205 °C (dec.)(lit.)
• Boiling Point: 235.3 °C at 760 mmHg
• Flash Point: 96.1 °C
• Appearance: /
• Vapor Pressure: 0.0408mmHg at 25°C
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: METHYL PIPECOLINATE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL PIPECOLINATE HYDROCHLORIDE(32559-18-5)
• EPA Substance Registry System: METHYL PIPECOLINATE HYDROCHLORIDE(32559-18-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 32559-18-5(Hazardous Substances Data)

Usage

Uses

Methyl Pipecolinate Hydrochloride is a reactant for synthesis of a pipecolic linker and antiviral agents.

General Description

Methyl pipecolinate hydrochloride is a hydrochloride salt of methyl piperidine-2-carboxylate (methyl pipecolinate). The kinetics of the enzymatic separation of enantiomeric forms of methyl pipecolinate using Candida antarctica Lipase A (CAL-A) has been reported. Its role as catalyst for the standard Diels-Alder reaction has been examined.

InChI:InChI=1/C7H13NO2.ClH/c1-10-7(9)6-4-2-3-5-8-6;/h6,8H,2-5H2,1H3;1H

Upstream product

• 67-56-1 methanol 
• 4043-87-2 pipecolic Acid 
• 111479-60-8 methyl (2RS)-6-oxopiperidine-2-carboxylate 
• 38195-81-2 1-oxy-pyridine-2-carboxylic acid methyl ester 

Downstream Products

• 139456-27-2 4-Acetyl-2-(4-chloro-phenyl)-7,8,9,9a-tetrahydro-2H,6H-pyrido[1,2-d][1,2,4]triazin-1-one 
• 132910-79-3 (+/-) methyl N-tert-butyloxycarbonyl 2-piperidinecarboxylate 
• 124619-69-8 1-benzylpiperidine-2-carboxylic acid methyl ester 
• 99720-01-1 methyl N-benzoyl-2-piperidine carboxylate 
• 200006-72-0 N-[(3-oxo-3-phenyl)propyl]pipecolic acid methyl ester 
• 208256-79-5 1-[N-(3,5-difluorophenylacetyl)-L-alaninyl]piperidine-2-carboxylate methyl ester 
• 210917-27-4 methyl 1-[4-(4-chlorophenyl)piperazine-1-sulfonyl]-piperidine-2-(RS)-carboxylate 
• 53941-92-7 N-methyl-2-piperidinecarboxamide 
• 19889-77-1 (RS)-piperidine-2-carboxamide 
• 4705-52-6 6,7,8,8a-tetrahydro-5H-imidazo[1,5-a]pyridine-1,3(2H,5H)-dione 
• 157634-02-1 tert-butyl 2-formylpiperidine-1-carboxylate 

Relevant articles and documents

Synthesis of bicyclic pyrazinones via addition of heterocyclic amines to a nitro-alkene

Michael addition of heterocyclic amines (6), (10), (13) and (17) to nitro- olefin (3) followed by reduction/cyclization of the nitro group of the adduct provides a convenient synthesis of the bicyclic pyrazinones (8), (12), (16), (19) and (20) which are found in several natural products.

Heterocyclic lactam derivative and purpose thereof as a bactericidal agent for crop pathogenic bacteria

The invention discloses a heterocyclic lactam derivative. The heterocyclic lactam derivative has a structure as shown by a formula (I). The invention also discloses a purpose of the compound as a bactericidal agent for crop pathogenic bacteria. A test result shows that the compound shown by the formula (I) has better bactericidal activity to gibberella zeae, magnapothe grisea, sclerotinia sclerotiorum, altermaria alternate, colletotrichum fructicola sinensis miyake and phomopsis adianticola when being 100ppm or below, and further, has the activity which is obviously higher than that of a heterocyclic lactaminol intermediate, and therefore, the heterocyclic lactam derivative has a great application prospect in the aspects of the comprehensive prevention and treatment of the crop pathogenicbacteria.(The formula is shown in the description.).

Captopril analogues as metallo-β-lactamase inhibitors

A number of captopril analogues were synthesised and tested as inhibitors of the metallo-β-lactamase IMP-1. Structure–activity studies showed that the methyl group was unimportant for activity, and that the potencies of these inhibitors could be best improved by shortening the length of the mercaptoalkanoyl side-chain. Replacing the thiol group with a carboxylic acid led to complete loss of activity, and extending the length of the carboxylate group led to decreased potency. Good activity could be maintained by substituting the proline ring with pipecolic acid.