19909-85-4

Basic information

• Product Name: 1-(Dichlorophosphino)-4-methoxybenzene
• Synonyms: (p-Methoxyphenyl)dichlorophosphine;1-(Dichlorophosphino)-4-methoxybenzene;4-Methoxyphenyldichlorophosphine
• CAS NO: 19909-85-4
• Molecular Formula: C₇H₇Cl₂OP
• Molecular Weight: 209.01
• Mol File: 19909-85-4.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(Dichlorophosphino)-4-methoxybenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(Dichlorophosphino)-4-methoxybenzene(19909-85-4)
• EPA Substance Registry System: 1-(Dichlorophosphino)-4-methoxybenzene(19909-85-4)

Safety Data

• Hazardous Substances Data: 19909-85-4(Hazardous Substances Data)

Usage

General Description

1-(Dichlorophosphino)-4-methoxybenzene is a chemical compound with the formula C7H7Cl2OP. It is a substituted phosphine ligand, which is commonly used in organometallic and coordination chemistry for its ability to bind to metal ions to form stable complexes. 1-(Dichlorophosphino)-4-methoxybenzene has a benzene ring with a methoxy group and two chlorine atoms attached to a phosphorus atom, making it a versatile and useful compound in chemical synthesis and catalysis. It is also used in the production of pharmaceuticals, agrochemicals, and other industrial applications. The compound is known for its strong coordination ability and high stability, making it an important building block for various chemical reactions and processes.

Upstream product

• 2097-72-5 bis(p-anisyl)mercury 
• 100-66-3 methoxybenzene 
• 93296-09-4 4-methoxyphenylzinc chloride 

Downstream Products

• 1019-70-1 chloro-(4-methoxy-phenyl)-phenyl-phosphine 
• 172422-36-5 C₁₁H₁₁F₆O₃P 
• 79995-25-8 (p-methoxyphenyl)bis(o-methoxyphenyl)phosphane 
• 1056473-75-6 N,N'-dibenzyl-N,N'-dimethyl-P-(4-methoxyphenyl)phosphonic diamide 
• 16513-36-3 pentakis(-methoxyphenyl)cyclopentaphosphine 
• 92789-73-6 di(n-butyl)(p-methoxyphenyl)phosphine 

Relevant articles and documents

Hydrogen/Halogen Exchange of Phosphines for the Rapid Formation of Cyclopolyphosphines

The hydrogen/halogen exchange of phosphines has been exploited to establish a truly useable substrate scope and straightforward methodology for the formation of cyclopolyphosphines. Starting from a single dichlorophosphine, a sacrificial proton "donor phosphine"makes the rapid, mild synthesis of cyclopolyphosphines possible: reactions are complete within 10 min at room temperature. Novel (aryl)cyclopentaphosphines (ArP)5 have been formed in good conversion, with the crystal structures presented. The use of catalytic quantities of iron(III) acetylacetonate provides significant improvements in conversion in the context of diphosphine (Ar2P)2 and alkyl-substituted cyclotetra- or cyclopentaphosphine ((AlkylP)n, where n = 4 or 5) formation. Both iron-free and iron-mediated reactions show high levels of selectivity for one specific ring size. Finally, investigations into the reactivity of Fe(acac)3 suggest that the iron species is acting as a sink for the hydrochloric acid byproduct of the reaction.

A direct and new convenient oxidation: Synthesis of substituted arylphosphonates from aromatics

An easy synthesis of aryl phosphonates by oxidation from aryldichlorophosphines with iodine in good yields is described. Aryldichlorophosphines are obtained by reaction of phosphorous trichloride with some aromatics in presence of various Lewis acids. BiCl3 and Bi(OTf)3 are used for the first time and bismuth trichloride is, for the first time in the case of anisole or thioanisole phosphonylation, used as a true regenerable Lewis acid catalyst in a reaction of direct phosphonylation of aromatics.

SYNTHESIS OF PHOSPHONIC DICHLORIDES AND CORRELATION OF THEIR P-31 CHEMICAL SHIFTS

Various mono-substituted diethyl arylphosphonates were prepared in good yield by treatment of aryl bromides or iodides with triethyl phosphite in the presence of NiCl2 or alternatively, addition of the aryl grignard reagent to diethyl phosphorochloridate.