199111-93-8

Upstream product

• 1452-63-7 picolinic acid hydrazide 
• 195818-65-6 C₁₃H₁₁FN₄OS 
• 1544-68-9 4-fluorophenyl isothiocyanate 
• 19182-34-4 ammonium p-fluorophenyldithiocarbamate 
• 371-40-4 4-fluoroaniline 

Downstream Products

• 1391942-94-1 C₁₄H₁₁FN₄S 

Relevant academic research and scientific papers

Synthesis and antimicrobial activity of some new 1,2,4-trizoles

A series of 1,2,4-triazole derivatives were synthesized using appropriate synthetic route and structures were confirmed by IR,1H NMR and elemental analysis. All the synthesized compounds (6a-6h and 7a-7h) were evaluated for antimicrobial activity by determining their minimum inhibitory concentrations (MICs) against a panel of Gram-positive, Gram-negative bacteria and fungi. Most of the compounds showed significant antimicrobial activity against Gram-positive bacteria viz. S. aureus, B. subtilis, Gram-negative bacteria viz. E. coli, P. aerugenosa and fungi viz. C. albicans, A. niger. Some of the compounds showed better antibacterial activities against Gram-positive bacteria compared to Gram-negative bacteria. Compounds 7g, 6g, 6a exhibited good MICs against Gram-positive bacteria and 7f showed better MICs against Gram-negative bacteria compared to reference norfloxacin. Compounds 7f and 7d exhibited MICs which is equipotent to the reference drug ketoconazole.

Synthesis, structure and alkylation of 4-(4-Fluoro phenyl)-5-(isomeric pyridyl)-1,2,4-triazole-3-thiole

New 3,5-disubstituted-1,2,4-triazole and their derivatives 3(a-c) were synthesized in excellent yield by the intra molecular cyclization of 1,4- disubstituted thiosemicarbazides 2(a-c) with sodium hydroxide. Their further alkylation with methyl iodide in

Selective synthesis and characterization of substituted 1,3,4-thiadiazole/oxadiazole and 1,2,4-triazole heterocyclic rings

A new series of 5-(isomeric pyridyl)-1,3,4-thiadiazole 3(a-c)/oxadiazole 6(a-c) and 4-(4-fluoro phenyl)-5-(isomeric pyridyl)-1,2,4-triazole- 3-thiol 4(a-c)/3-methyl thiol 5(a-c) derivatives were synthesized in excellent yield and under different condition