199172-08-2

Upstream product

• 591-20-8 3-Bromophenol 
• 24214-73-1 cyclohexylhydrazine hydrochloride 
• 215815-08-0 5-bromo-2-propionylphenyl methanesulfonate 
• 6498-34-6 cyclohexylhydrazine 

Relevant academic research and scientific papers

THERAPEUTICALLY ACTIVE COMPOUNDS BASED ON INDAZOLE BIOISOSTERE REPLACEMENT OF CATECHOL IN PDE4 INHIBITORS

Therapeutically active compositions of matter are described which are useful for treating or preventing diseases and conditions comprising inflammatory diseases including joint inflammation, Crohn's disease, and inflammatory bowel disease; respiratory dis

The synthesis of a selective PDE4/TNFα inhibitor

Two syntheses of cis-4-cyano-4-(1-cyclohexyl-3-ethyl-1H-indazol-6-yl)cyclohexanecarboxylic acid (1), a selective PDE4/TNFα inhibitor are described. The first synthesis relied on a solvolysis of a tertiary benzylic alcohol to the nitrile using T

Substituted indazole derivatives and related compounds

The invention relates to compounds of the formula I and pharmaceutically acceptable salts thereof, wherein R2aand R2bare independently selected from the group consisting essentially of hydrogen and hereinafter recited substituents, provided that one, but not both of R2aand R2bmust be independently selected as hydrogen, wherein said substituents comprise: wherein the dashed lines in formulas (Ia) and (Ib) independently and optionally represent a single or double bond, provided that in formula (Ia) both dashed lines cannot both represent double bonds at the same time; and R, R1, R3, R4, R5, R6, R7, R18and m are as defined. The invention further relates to intermediates for the preparation of the compounds of formula I, and to pharmaceutical compositions containing, and methods of using, the compounds of formula I, or acceptable salts thereof, for the inhibition of phosphodiesterase (PDE) type IV or the production of tumor necrosis factor (TNF) in a mammal.

Processes and intermediates for preparing substituted indazole derivatives

PCT No. PCT/IB98/00647 Sec. 371 Date May 27, 1999 Sec. 102(e) Date May 27, 1999 PCT Filed Apr. 28, 1998 PCT Pub. No. WO98/50367 PCT Pub. Date Nov. 12, 1998The invention relates to processes and intermediates for preparing compounds of formula (I) and phar

Substituted indazole derivatives and related compounds

The invention relates to compounds of the formula I and pharmaceutically acceptable salts thereof, wherein R2a and R2b are independently selected from the group consisting essentially of hydrogen and hereinafter recited substituents, provided that one, bu

A versatile and efficient synthesis of substituted 1H-indazoles

A facile synthesis of substituted 1H-indazole 4 from aryl mesylate 3 is described. The reaction, which proceeds through the intermediate hydrazone, was general with regard to the substituents on the arene and was applicable to several hydrazines. It was a