19922-23-7Relevant academic research and scientific papers
Solid-phase parallel synthesis of 5-amino- and 5-amido-1,2,4-thiadiazole derivatives via cyclization reactions of a carboxamidine thiourea linker
Ryu, In Ae,Park, Joo Yeon,Han, Hyea Chul,Gong, Young-Dae
experimental part, p. 999 - 1003 (2009/10/10)
A general method is described for the solid-phase parallel synthesis of 5-amino- and 5-amido-l,2,4-thiadiazoles. The sequence developed for this purpose is based on cyclization reactions of resin-bound carboxamidine thioureas promoted by p-toluenesulfonyl
Thiazole and thiadiazole analogues as a novel class of adenosine receptor antagonists
Van Muijlwijk-Koezen,Timmerman,Vollinga,Frijtag von Drabbe Künzel,De Groote,Visser,IJzerman
, p. 749 - 762 (2007/10/03)
Novel classes of heterocyclic compounds as adenosine antagonists were developed based on a template approach. Structure-affinity relationships revealed insights for extended knowledge of the receptor-ligand interaction. We replaced the bicyclic heterocycl
