19922-82-8

Basic information

• Product Name: 2-broMo-1-(4-nitrophenyl)ethanol
• Synonyms: 2-broMo-1-(4-nitrophenyl)ethanol
• CAS NO: 19922-82-8
• Molecular Formula: C₈H₈BrNO₃
• Molecular Weight: 246.05802
• EINECS: -0
• Mol File: 19922-82-8.mol
• Article Data: 14

Chemical Properties

• Melting Point: 86-87 °C
• Boiling Point: 365.8°C at 760 mmHg
• Flash Point: 175°C
• Appearance: /
• Density: 1.69g/cm³
• Vapor Pressure: 5.41E-06mmHg at 25°C
• Refractive Index: 1.627
• PKA: 12.26±0.20(Predicted)
• CAS DataBase Reference: 2-broMo-1-(4-nitrophenyl)ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-broMo-1-(4-nitrophenyl)ethanol(19922-82-8)
• EPA Substance Registry System: 2-broMo-1-(4-nitrophenyl)ethanol(19922-82-8)

Safety Data

• Hazardous Substances Data: 19922-82-8(Hazardous Substances Data)

Usage

General Description

2-Bromo-1-(4-nitrophenyl)ethanol, also known as 4-Bromo-2-hydroxy-1-nitrophenylethane, is a chemical compound with the molecular formula C8H8BrNO3. It is a white to off-white crystalline powder and is commonly used in organic synthesis and pharmaceutical research. This chemical is known for its antimicrobial and antifungal properties, making it a valuable ingredient in the production of pharmaceuticals and personal care products. Additionally, 2-Bromo-1-(4-nitrophenyl)ethanol has been found to have potential as a corrosion inhibitor in metal surface treatments. However, it is important to handle this chemical with care, as it can be harmful if swallowed, inhaled or comes into contact with the skin.

InChI:InChI=1/C8H8BrNO3/c9-5-8(11)6-1-3-7(4-2-6)10(12)13/h1-4,8,11H,5H2

Upstream product

• 100-13-0 4-nitrostyrene 
• 6388-74-5 p-Nitrophenyloxirane 
• 100-19-6 (4-nitrophenyl)ethanone 
• 99-81-0 4-Nitrophenacyl bromide 

Downstream Products

• 6388-74-5 p-Nitrophenyloxirane 
• 6388-74-5 (2R)-2-(4-nitrophenyl)oxirane 
• 6388-74-5 (S)-2-(4-nitrophenyl)oxirane 
• 26086-61-3 2-azido-1-(4-nitrophenyl)ethan-1-one 
• 325856-42-6 rac-2-azido-2-(para-nitro-phenyl)-ethanol 
• 397869-61-3 (S)-2-azido-1-(4-nitrophenyl)ethan-1-ol 
• 861062-77-3 N-acetyl-sulfanilic acid-(4-indolizin-2-yl-anilide) 
• 139705-73-0 2-(4-aminophenyl)indolizine 
• 125653-67-0 (R)-(-)-2-bromo-1-(4-nitrophenyl)ethanol 
• 849359-49-5 1-butanoyloxy-2-bromo-1-(4-nitrophenyl)ethane 
• 90844-84-1 1-acetoxy-2-bromo-1-(4-nitrophenyl)ethane 
• 99-81-0 4-Nitrophenacyl bromide 
• 54149-11-0 2-(4-nitrophenyl)indolizine 
• 18462-34-5 (Z)-1-(2-bromovinyl)-4-nitrobenzene 

Relevant articles and documents

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Tandem transfer hydrogenation-epoxidation of ketone substrates catalysed by alkene-tethered Ru(ii)-NHC complexes

A series of nine cyclopentadienyl Ru(ii)-NHC complexes (1-9) have been synthesised by systematically varying the ligand and/or ligand substituents: η5-C5H4R′ (R′ = H, Me), EPh3 (E = P, As), NHC (Im, BIm), where NHC = Im(R)(R′) (R, R′ = Me, Bn, 4-NO2Bn, C2H4Ph, C4H7). Each of the Ru(ii)-NHC complexes features an N-alkenyl tether to attain bidentate NHC ligands. All complexes found application as catalysts in the tandem transfer hydrogenation and epoxidation reactions of carbonyl substrates. The catalytic activity of the complexes was shown to be similar, with efficiencies of up to 69% conversion after 18 hours and varying alcohol:epoxide selectivity for a variety of electronically diverse carbonyl substrates. Complex 3, with a nitro-containing substituent on the NHC ligand, was the only complex that showed preference for the alcohol product over the epoxide after 18 hours of reaction time.

Azidolysis of epoxides catalysed by the halohydrin dehalogenase from Arthrobacter sp. AD2 and a mutant with enhanced enantioselectivity: an (S)-selective HHDH

Halohydrin dehalogenase from Arthrobacter sp. AD2 catalysed azidolysis of epoxides with high regioselectivity and low to moderate (S)-enantioselectivity (E?=?1–16). Mutation of the asparagine 178 to alanine (N178A) showed increased enantioselectivity towards styrene oxide derivatives and glycidyl ethers. Conversion of aromatic epoxides was catalysed by HheA-N178A with complete enantioselectivity, however the regioselectivity was reduced. As a result of the enzyme-catalysed reaction, enantiomerically pure (S)-β-azido alcohols and (R)-α-azido alcohols (ee???99%) were obtained.