199341-35-0

Basic information

• Product Name: [(4R)-(+)-4-(2-methoxy-2-oxoethyl)-5-oxo-1,3-dioxolan-4-yl]acetic acid
• CAS NO: 199341-35-0
• Molecular Weight: 218.163
• Mol File: 199341-35-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: [(4R)-(+)-4-(2-methoxy-2-oxoethyl)-5-oxo-1,3-dioxolan-4-yl]acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: [(4R)-(+)-4-(2-methoxy-2-oxoethyl)-5-oxo-1,3-dioxolan-4-yl]acetic acid(199341-35-0)
• EPA Substance Registry System: [(4R)-(+)-4-(2-methoxy-2-oxoethyl)-5-oxo-1,3-dioxolan-4-yl]acetic acid(199341-35-0)

Safety Data

• Hazardous Substances Data: 199341-35-0(Hazardous Substances Data)

Upstream product

• 184834-31-9 [-(2-methoxy-2-oxoethyl)-5-oxo-1,3-dioxolan-4-yl]acetic acid 
• 77862-72-7 (5-oxo-[1,3]dioxolane-4,4-diyl)-bis-acetic acid dimethyl ester 
• 144-16-1 5-oxo-1,3-dioxolan-4-ylidenedi(acetic acid) 
• 4767-12-8 4,4-(5-oxo-1,3-dioxolane)diacetic acid anhydride 
• 77-92-9 citric acid 
• 199341-36-1 C₈H₁₀O₇*C₈H₁₁N 

Downstream Products

• 173934-26-4 (R)-(-)-homocitric acid lactone 

Relevant articles and documents

An improved synthesis of trisodium (U)-homocitrate from citric acid

A method of synthesis of trisodium (R)-homocitrate starting from citric acid is reported. The procedure affords the final product of high optical purity with satisfactory yield.

Resolution of a citric acid derivative: Synthesis of (R)-(-)-homocitric acid-γ-lactone

Both the (R) and (S) enantiomers of the citric acid derivative 1 have been obtained in ≤90% ee via resolution of the racemate by fractional crystallisation of the (S) and (R)-α-methylbenzylamine salts respectively. The stereochemistry of (R)-1 has been assigned by its conversion to (R)-(-)- homocitric acid utilising an Amdt-Eistert homologation followed by acid eatalysed deprotection.