19935-81-0

Basic information

• Product Name: Benzene, 1-(1-broMoethyl)-4-nitro-
• Synonyms: Benzene, 1-(1-broMoethyl)-4-nitro-;1-(1-BroMoethyl)-4-nitrobenzene
• CAS NO: 19935-81-0
• Molecular Formula: C₈H₈BrNO₂
• Molecular Weight: 230.05862
• Mol File: 19935-81-0.mol
• Article Data: 17

Chemical Properties

• Melting Point: 31-32.5 °C
• Boiling Point: 152-153 °C(Press: 5 Torr)
• Appearance: /
• Density: 1.554±0.06 g/cm3(Predicted)
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• CAS DataBase Reference: Benzene, 1-(1-broMoethyl)-4-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-(1-broMoethyl)-4-nitro-(19935-81-0)
• EPA Substance Registry System: Benzene, 1-(1-broMoethyl)-4-nitro-(19935-81-0)

Safety Data

• Hazardous Substances Data: 19935-81-0(Hazardous Substances Data)

Usage

General Description

"Benzene, 1-(1-bromoethyl)-4-nitro-" is a chemical compound with the formula C8H8BrNO2. It is a nitro compound, with a bromine atom attached to a 1-(1-bromoethyl) group. Benzene, 1-(1-bromoethyl)-4-nitro- is used in various chemical reactions and processes, including organic synthesis and pharmaceutical manufacturing. It is a yellow to orange crystalline solid, and is considered to be hazardous and potentially harmful to health and the environment. It should be handled with care and according to proper safety protocols.

Upstream product

• 6531-13-1 1-[4-nitrophenyl]-1-ethanol 
• 128-08-5 N-Bromosuccinimide 
• 100-12-9 4-ethylnitrobenzene 
• 100-19-6 (4-nitrophenyl)ethanone 
• 100-27-6 2-(4-nitrophenyl)ethanol 
• 603-35-0 triphenylphosphine 
• 6531-13-1 (+)-1-(4'-nitrophenyl)ethanol 
• 19910-33-9 2-(4-nitrophenyl)propanoic acid 
• 100-13-0 4-nitrostyrene 
• 19935-81-0 1-(4'-nitrophenyl)bromoethane 

Downstream Products

• 100316-97-0 diethyl-[1-(4-nitro-phenyl)-ethyl]-amine 
• 100-13-0 4-nitrostyrene 
• 18755-62-9 α.β-Dimethyl-p-nitro-styrol 
• 42142-22-3 (R,S)-NN-dimethyl-1-p-nitrophenylethylamine 
• 100-19-6 (4-nitrophenyl)ethanone 
• 62-23-7 4-nitro-benzoic acid 
• 1065330-32-6 C₂₁H₂₄N₂O₄ 
• 1064708-74-2 N-(p-nitrophenylethyl)-4-benzoylmethyl-4-piperidinol hydrochloride 
• 1066-44-0 trimethyltin bromide 
• 169059-35-2 (1-(4-nitrophenyl)ethyl)(phenyl)sulfane 
• 36806-79-8 N-[1-(4-nitro-phenethyl)-piperidin-4-yl]-benzamide 
• 105838-72-0 4-(1-diethylamino-ethyl)-aniline 
• 111654-24-1 3-phenoxybenzyl 3-methyl-3-p-nitrophenylpropionate 

Relevant articles and documents

Decarboxylative Bromination of Sterically Hindered Carboxylic Acids with Hypervalent Iodine(III) Reagents

Sterically hindered three-dimensional (3D) alkyl halides are promising precursors for various reactions; however, they are difficult to synthesize via conventional reactions. We present an efficient and practical method for decarboxylative bromination of sterically hindered 3D aliphatic carboxylic acids using commercially available (diacetoxyiodo)benzene and potassium bromide, one of the most stable and cheapest bromine sources in nature. The present method features a metal-free/Br2-free system, mild reaction conditions, one-pot operation under air at room temperature, wide functional group compatibility, and gram-scale synthetic capability. This highly efficient reaction cleanly converts a broad range of carboxylic acids, the most inexpensive and readily available sources of highly strained/naturally occurring/drug-related scaffolds, into the corresponding alkyl bromides in good to high yields.

Dual copper- and photoredox-catalysed C(sp2)-C(sp3) coupling

The use of copper catalysis with visible light photoredox catalysis in a cooperative fashion has recently emerged as a versatile means of developing new C-C bond forming reactions. In this work, dual copper and photoredox catalysis is exploited to effect C(sp2)-C(sp3) cross-couplings between aryl boronic acids and benzyl bromides.

Scalable anti-Markovnikov hydrobromination of aliphatic and aromatic olefins

To improve access to a key synthetic intermediate we targeted a direct hydrobromination-Negishi route. Unsurprisingly, the anti-Markovnikov addition of HBr to estragole in the presence of AIBN proved successful. However, even in the absence of an added initiator, anti-Markovnikov addition was observed. Re-examination of early reports revealed that selective Markovnikov addition, often simply termed "normal" addition, is not always observed with HBr unless air is excluded, leading to the rediscovery of a reproducible and scalable initiator-free protocol.