199388-01-7Relevant articles and documents
Copper-catalyzed selective C-O bond formation by oxidative α-C(sp3)-H/O-H coupling between ethers and salicylaldehydes
Barve, Balaji D.,Wu, Yang-Chang,El-Shazly, Mohamed,Korinek, Michal,Cheng, Yuan-Bin,Wang, Jeh-Jeng,Chang, Fang-Rong
, p. 2290 - 2297 (2015/03/30)
Copper-catalyzed oxidative coupling of ethers and salicylaldehydes, via the direct α-C(sp3)-H bond functionalization of ethers in the presence tert-butyl hydroperoxide as an oxidant has been explored. The corresponding acetals were selectively
Regioselective synthesis of 6-substituted 2-hydroxybenzaldehyde: Efficient synthesis of the immunomodulator tucaresol and related analogues
Zacharie, Boulos,Attardo, Giorgio,Barriault, Nancy,Penney, Christopher
, p. 2925 - 2929 (2007/10/03)
Two new improved procedures have been developed for the preparation of the immunostimulant tucaresol 1 [4-(2-formyl-3-hydroxyphenoxymethyl)benzoic acid]. These approaches, which start from resorcinol or 2,6-dimethoxybenzaldehyde, are practical and therefore amenable to scale-up. In the case of the second approach, the multi-step synthesis reported in the literature has been reduced to three steps. Furthermore, unlike the reported method, our synthesis is versatile for the preparation of tucaresol analogues. The method is general and applicable for the preparation of 6-substituted 2-hydroxybenzaldehydes.
