664324-22-5Relevant academic research and scientific papers
Tucaresol derivative and use thereof
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Paragraph 0211; 0218; 0237-0241, (2021/05/12)
The invention discloses a tucaresol derivative compound, a composition comprising the tucaresol derivative compound, a method for enhancing an immune response in an individual by administering the tucaresol derivative compound or by co-administering the tucaresol derivative compound and one or more additional agents, and use of the tucaresol derivative compound and the composition comprising the tucaresol derivative compound in preparation of a medicament for treating cancer in an individual or enhancing an immune response in an individual.
TUCARESOL DERIVATIVES AND USES THEREOF
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Paragraph 0193, (2021/05/21)
Disclosed herein are tucaresol derivative compound and composition containing the same. Also disclosed herein are methods of enhancing immune response in a subject by administering the tucaresol derivative compound or by co-administering the tucaresol derivative compound and one or more additional agents. Also disclosed herein are use of the tucaresol derivative compound and composition containing the same in the manufacture of a medicament for treating cancer or enhancing immune response in a subject.
NOVEL USE OF BENZOTHIAZOLE DERIVATIVES
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Page 29, (2008/06/13)
The use of compounds of formula (I) wherein X, A, B, D, R1 and R2 are as defined in the Specification and pharmaceutically acceptable salts thereof in the manufacture of a medicament for the treatment or prophylaxis of diseases or conditions in which inhibition of kinase Itk activity is beneficial is disclosed. Certain novel compounds of formula (I), together with processes for their preparation, compositions containing them and their use in therapy are also disclosed.
Regioselective synthesis of 6-substituted 2-hydroxybenzaldehyde: Efficient synthesis of the immunomodulator tucaresol and related analogues
Zacharie, Boulos,Attardo, Giorgio,Barriault, Nancy,Penney, Christopher
, p. 2925 - 2929 (2007/10/03)
Two new improved procedures have been developed for the preparation of the immunostimulant tucaresol 1 [4-(2-formyl-3-hydroxyphenoxymethyl)benzoic acid]. These approaches, which start from resorcinol or 2,6-dimethoxybenzaldehyde, are practical and therefore amenable to scale-up. In the case of the second approach, the multi-step synthesis reported in the literature has been reduced to three steps. Furthermore, unlike the reported method, our synthesis is versatile for the preparation of tucaresol analogues. The method is general and applicable for the preparation of 6-substituted 2-hydroxybenzaldehydes.
