199460-69-0

Basic information

• Product Name: 4-(2-fluorophenyl)-1-(pyridin-4-yl)carbonylthiosemicarbazide
• Synonyms: 4-(2-fluorophenyl)-1-(pyridin-4-yl)carbonylthiosemicarbazide
• CAS NO: 199460-69-0
• Molecular Weight: 290.321
• Mol File: 199460-69-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 4-(2-fluorophenyl)-1-(pyridin-4-yl)carbonylthiosemicarbazide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-fluorophenyl)-1-(pyridin-4-yl)carbonylthiosemicarbazide(199460-69-0)
• EPA Substance Registry System: 4-(2-fluorophenyl)-1-(pyridin-4-yl)carbonylthiosemicarbazide(199460-69-0)

Safety Data

• Hazardous Substances Data: 199460-69-0(Hazardous Substances Data)

Upstream product

• 1570-45-2 isonicotinic acid ethylester 
• 54-85-3 isoniazid 
• 38985-64-7 o-fluorophenyl isothiocyanate 

Downstream Products

• 704873-76-7 4-(2-fluorophenyl)-3-(pyridin-4-yl)-1,2,4-triazolin-5-thione 

Relevant articles and documents

Synthesis, antibacterial and antiproliferative potential of some new 1-pyridinecarbonyl-4-substituted thiosemicarbazide derivatives

In this study, the antibacterial, cytotoxic and antiproliferative activities of novel thiosemicarbazide derivatives were assessed. Our results demonstrated that some of the novel compounds possess good antibacterial properties against Staphylococcus epidermidis, Streptococcus mutans and Streptococcussanguinis and are only slightly cytotoxic; thus, they exhibit an excellent therapeutic index, which is higher than that of ethacridine lactate. Moreover, our data showed that compounds 2 and 4 have an antiproliferative activity against human breast adenocarcinoma and human hepatocellular carcinoma cell lines. We expect that the novel thiosemicarbazide derivatives can be used as agents for treatment of dental caries and also for chemotherapy support.

Synthetic nicotinic/isonicotinic thiosemicarbazides: In vitro urease inhibitory activities and molecular docking studies

Nicotinic and isonicotinic thiosemicarbazide or hydrazine carbothioamides 3–27 were synthesized and the structures of synthetic compounds were elucidated by various spectroscopic techniques such as EI-MS, 1H-, and 13C NMR. Synthetic derivatives were evaluated for their urease inhibitory activity which revealed that except few all derivatives demonstrated excellent inhibition in the range of IC50 values of 1.21–51.42 μM as compared to the standard thiourea (IC50 = 21.25 ± 0.13 μM). Among the twenty-five synthetic derivatives nineteen 1–5, 7, 8, 10, 12, 14–18, 20–22, 24–27 were found to be more active showing IC50 values between 1.13 and 19.74 μM showing superior activity than the standard. Limited structure-activity relationship demonstrated that the positions of substituent as well as position of nitrogen in pyridine ring are very important for inhibitory activity of this class of compound. To verify these interpretations, in silico study was also performed. A good correlation was obtained between the biological evaluation of active compounds and docking study.