19948-85-7Relevant academic research and scientific papers
Synthesis, biological evaluation, and molecular docking studies of 1,3,4-thiadiazol-2-amide derivatives as novel anticancer agents
Yang, Xian-Hui,Xiang, Lu,Li, Xi,Zhao, Ting-Ting,Zhang, Hui,Zhou, Wen-Ping,Wang, Xiao-Ming,Gong, Hai-Bin,Zhu, Hai-Liang
experimental part, p. 2789 - 2795 (2012/07/27)
A series of 1,3,4-thiadiazol-2-amide derivatives (5a-5y) have been designed and synthesized, and their biological activities were also evaluated as potential antiproliferation and FAK inhibitors. Among all the compounds, 5h showed the most potent activity
Synthesis of 6-Aroylimino-2-aryl-1,3,4-thiadiazolothiadiazolines
Sridevi, G.,Rao, P. Jayaprasad,Reddy, K. Kondal
, p. 997 - 1000 (2007/10/02)
Reaction of 2-amino-5-aryl-1,3,4-thiadiazoles (V) with aroyl isothiocyanates gives 2-aroylamino-5-aryl-1,3,4-thiadiazoles (VII) and N-aroyl-N'-(5-aryl-1,3,4-thiadiazol-2-yl)thioureas (VIII).Contrary to earlier reports, cyclisation of VIII in the presence of PCl5 in POCl3 yields 6-aroylimino-2-aryl-1,3,4-thiadiazolo-thiadiazolines (X).Cyclisation of VIII in the presence of other oxidising agents also leads to X.
Synthesis of s-Triazolo-thiadiazoles
Ramachandraiah, G.,Reddy, K. Kondal
, p. 908 - 909 (2007/10/02)
1-(5-Aryl-1,3,4-thiadiazol-2-yl)-5-aryltetrazoles (VI) have been obtained by the reaction of 2-aroylamino-5-aryl-1,3,4-thiadiazoles (IV) with phosphorus pentachloride and azidolysis of the resulting imidoyl chlorides.The products obtained on thermolysis o
