199480-36-9

Usage

Structure

A five-membered heterocyclic compound containing two nitrogen atoms, with one methyl and one ethyl ester group.

Type

Ester, formed from the reaction of a carboxylic acid and an alcohol.

Uses

Commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals.

Fields of interest

Medicinal chemistry and organic chemistry.

Upstream product

• 37687-24-4 diethyl 1H-pyrazole-3,5-dicarboxylate 
• 74-88-4 methyl iodide 
• 36983-35-4 ethyl 4-(furan-2-yl)-2,4-dioxobutyrate 
• 104296-35-7 3-(ethoxycarbonyl)-5-(2-furyl)-1-methylpyrazole 

Downstream Products

• 1078709-28-0 N-(4-tert-butylbenzyl)-4-chloro-3-formyl-1-methyl-1H-pyrazole-5-carboxamide 
• 1078709-27-9 N-(4-tert-butylbenzyl)-4-chloro-3-ethoxycarbonyl-1-methyl-1H-pyrazole-5-carboxamide 

Relevant academic research and scientific papers

NOVEL INDAZOLE COMPOUND OR SALT THEREOF

An indazole compound represented by the following Formula (I) or a salt thereof: wherein X, R1, R2, ring A, L1, L2, L3, and R5 are as defined in this specification.

ANTICANCER COMBINATION THERAPY WITH N-(1-ACRYLOYL-AZETIDIN-3-YL)-2-((1H-INDAZOL-3-YL)AMINO)METHYL)-1H-IMIDAZOLE-5-CARBOXAMIDE INHIBITOR OF KRAS-G12C

A method of treating cancer comprises administering: (a) a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof; and (b) a therapeutically effective amount of an additional anti-cancer agent, to a subject in need of such treatment, the compound of Formula (I) being: where X, R1, R2, ring A, L1, L2, L3, and R5 are as defined in this disclosure.

Synthesis of fluorinated and nonfluorinated tebufenpyrad analogues for the study of anti-angiogenesis MOA

In this contribution we report the synthesis of fluorinated and nonfluorinated tebufenpyrad analogues to explore potential druglike properties through the phenotypic screening as part of the Lilly Open Innovation Drug Discovery (OIDD) program.

Synthesis of new fluorinated tebufenpyrad analogs with acaricidal activity through regioselective pyrazole formation

(Chemical Equation Presented) In previous studies, our group has shown that the use of fluorinated alcohols such as trifluoroethanol (TFE) and hexafluoroisopropanol (HFIP) as solvents dramatically increases the regioselectivity in the pyrazole formation from 1,3-diketone with methylhydrazine. We have now applied this synthetic method to the preparation of new fluorinated pyrazoles, which have then been used as synthetic intermediates in the preparation of fluorinated analogs of Tebufenpyrad, a commercial acaricide. These compounds display a strong acaricidal activity that is either comparable to or better than that of the commercial compound.