199486-38-9

Upstream product

• 199486-35-6 (3S)-3-(4-fluoro-3-nitrophenyl)-2-<(2R)-2-(4-hydroxy-phenyl)-2-<2-(3-hydroxyphenyl)-acetylamino>acetylamino>-propionic acid methyl ester 
• 446-34-4 2-fluoro-4-methyl-1-nitrobenzene 
• 621-37-4 m-hydroxyphenylacetic acid 
• 199486-39-0 11(R)-11-(4-hydroxyphenyl)-9,12-dioxo-2-oxa-10,13-diaza-tricyclo-<14.2.2.1^3,7>heneicosa-1(19),3(21),4,6(20),17-hexaene-(14S)-14-carboxxylic acid methyl ester 
• 178744-40-6 (S)-2-[(R)-2-tert-Butoxycarbonylamino-2-(4-hydroxy-phenyl)-acetylamino]-3-(4-fluoro-3-nitro-phenyl)-propionic acid methyl ester 
• 199486-37-8 3-fluoro-4-nitrobenzylamine hydrochloride 
• 199486-36-7 (11R,14S)-11-(4-Hydroxy-phenyl)-9,12-dioxo-2-oxa-10,13-diaza-tricyclo[14.2.2.1^3,7]henicosa-1⁽¹⁹⁾,3⁽²¹⁾,4,6,16⁽²⁰⁾,17-hexaene-14-carboxylic acid 
• 188624-24-0 (RS)-N-trifluoroacetyl-4-fluoro-3-nitrophenylalanine methyl ester 
• 131858-37-2 4-(bromomethyl)-2-fluoro-1-nitrobenzene 
• 15017-52-4 4-(bromomethyl)-1-fluoro-2-nitrobenzene 
• 27460-85-1 N-(tert-butoxycarbonyl)-D-(4-hydroxyphenyl)glycine 

Relevant academic research and scientific papers

Synthetic studies towards western and eastern macropolypeptide subunits of Kistamycin

The western subunit (fused bicyclic 16+15 membered ring) was synthesized by sequential intramolecular S(N)Ar reaction and the first 17-membered ring compound as model of the eastern subunit was obtained by an intramolecular Ni0 mediated coupling reaction.

The first synthesis of 16+15-membered bicyclic polypeptide model of A- O-C-B-O-D rings of kistamicin

A 16+15 membered bicyclic polypeptide containing biaryl ether bonds, model of A-O-C-B-O-D rings of kistamicin has been synthesized by sequential intramolecular SN(Ar) reactions.