19949-93-0Relevant academic research and scientific papers
Zinc-mediated tandem-one-pot facile synthesis of 1-(arylsulfonyl) aryl/heteryl methanes: A case of C-S bond formation
Srinivas,Dubey
experimental part, p. 1584 - 1592 (2011/06/27)
Reaction of arylmethyl/heteryl methyl zinc chloride (generated in situ from aryl methyl and heteryl methyl chloride and zinc metal) with aryl sulfonyl chlorides in tetrahydrofuran (THF) under mild conditions (i.e., at room temperature) furnishes the corresponding 1-(aryl sulfonyl)aryl/heteryl methanes in good yields.
A facile solvent-free synthesis of 1-alkyl/aralkyl-2-(1-arylsulfonyl alkyl) benzimidazoles using "tBAB" as surface catalyst
Dubey,Prasada Reddy,Srinivas
experimental part, p. 1317 - 1322 (2010/12/29)
Reaction 2-(α-chloroalkyl)benzimidazoles 1 with aryl sulphinate sodium salt 2 under solvent-free conditions in the presence of tetrabutylammonium bromide as surface catalyst, by simple physical grinding using mortar and pestle, gives 1H-2-(α-arylsulfonylalkyl)benzimidazoles 3. The latter on treatment with alkylating agents under solvent-free conditions results in 1-alkyl/aralkyl-2-(α-arylsulfonylalkyl)benzimidazoles 4. Alternatively, 4 can also be prepared directly from 1-alkyl/aralkyl-2-(α- chloroalkyl)benzimidazoles 5 by reaction with 2, which in turn could be prepared by reaction of 1 with alkylating agents under solvent-free conditions and all these reactions are free from organic solvents including experimental procedures.
Synthesis of 1-alkyl/aralkyl-2-(1-arylsulfonylalkyl)benzimidazoles under PTC conditions
Dubey,Prasada Reddy,Srinivas
, p. 488 - 491 (2008/09/18)
2-(α-chloroalkyl)benzimidazoles 1 on reaction with arylsulphinate sodium salt 2, in CH3CN under PTC conditions, gives 3 which on alkylation yields 1-alky/aralkyl-2-(α-aryl sulfonylalkyl)benzimidazoles 4. Alternatively, 4 can also be prepared by the reaction of 2 with 1-alkyl/aralkyl-2-(α-chloroalkyl)benzimidazole 5 in CH3CN using triethylbenzylammonium chloride (TEBAC) as PTC. 5 are obtained from 1 in turn, by alkylation in CH3CN under PTC conditions.
Polyethyleneglycol Catalysed N-Sulphonylation and N-Benzoylation of Substituted Benzimidazoles
Kumar, P. Raja
, p. 1273 - 1274 (2007/10/02)
Benzenesulphonyl chloride and p-toluenesulphonyl chloride react with benzimidazole and 2-phenylbenzimidazole in benzene and 50percent aqueous sodium hydroxide in the presence of polyethyleneglycol 400 or triethylbenzylammonium chloride to afford the corresponding N-sulphonyl derivatives.However, 2-methylbenzimidazole affords both N-sulphonylated and C-sulphonylated products.N-Benzoylation is also effected under similar conditions using benzoyl chloride.
