1995-83-1Relevant academic research and scientific papers
Studies directed toward the asialoglycoprotein receptor mediated delivery of 5-fluoro-2′-deoxyuridine for hepatocellular carcinoma
Rico, Lorena,?stergaard, Michael E.,Bell, Melanie,Seth, Punit P.,Hanessian, Stephen
, p. 2652 - 2654 (2018)
The anticancer nucleoside 5-fluoro 2′-deoxyuridine-5′-phosphate (5-FdU-P) was attached via an amide chain linker to a triantennary GalNAc cluster as a means to deliver the drug to hepatic cells that recognize the amino sugar units.
New 3′-O-aromatic acyl-5-fluoro-2′-deoxyuridine derivatives as potential anticancer agents
Szymańska-Michalak, Agnieszka,Wawrzyniak, Dariusz,Framski, Grzegorz,Kujda, Marta,Zgo?a, Paulina,Stawinski, Jacek,Barciszewski, Jan,Boryski, Jerzy,Kraszewski, Adam
, p. 41 - 52 (2016)
New aromatic and aliphatic 3′-O-acyl-5-fluoro-2′-deoxyuridine derivatives were synthesized and evaluated as candidates for prodrugs against various cancer cell lines. As the most promising candidate for antimalignant therapeutics was found a dual-acting a
Regioselective acylation of nucleosides and their analogs catalyzed by Pseudomonas cepacia lipase: enzyme substrate recognition
Li, Ning,Zong, Min-Hua,Ma, Ding
supporting information; experimental part, p. 1063 - 1068 (2009/04/11)
The substrate recognition of Pseudomonas cepacia lipase in the acylation of nucleosides was investigated by means of rational substrate engineering for the first time. P. cepacia lipase displayed excellent 3′-regioselectivities (96 to >99%) in the lauroyl
