(2R,3S,5R)-5-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-(hydroxymethyl)tetrahydrofuran-3-yl benzoate

Base Information

Chemical Name:(2R,3S,5R)-5-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-(hydroxymethyl)tetrahydrofuran-3-yl benzoate
CAS No.:1995-83-1
Molecular Formula:C₁₆H₁₅FN₂O₆
Molecular Weight:350.303
Hs Code.:

Synonyms:(2R,3S,5R)-5-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-(hydroxymethyl)tetrahydrofuran-3-yl benzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3S,5R)-5-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-(hydroxymethyl)tetrahydrofuran-3-yl benzoate

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Technology Process of (2R,3S,5R)-5-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-(hydroxymethyl)tetrahydrofuran-3-yl benzoate

There total 7 articles about (2R,3S,5R)-5-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-(hydroxymethyl)tetrahydrofuran-3-yl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: (2R,3S,5R)-2-(((tert-butyldiphenylsilyl)oxy)methyl)-5-(5-fluoro-2,4-dioxo-3,4-hydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl benzoate

: 1995-83-1
(2R,3S,5R)-5-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-(hydroxymethyl)tetrahydrofuran-3-yl benzoate

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃;
DOI:10.1016/j.bmcl.2018.06.002

Reference yield: 88.0%

: 769-78-8,24991-32-0
vinyl benzoate

: 50-91-9
5-Fluoro-2'-deoxyuridine

: 1006381-74-3
5'-O-benzoyl-FUdR

: 1995-83-1
(2R,3S,5R)-5-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-(hydroxymethyl)tetrahydrofuran-3-yl benzoate

: 2691-71-6
3',5'-di-O-benzoyl-5-fluoro-2'-deoxyuridine

Guidance literature:: With PSL-C; 1-n-butyl-2,3-dimethylimidazolium hexafluorophosphate; In tetrahydrofuran; at 50 ℃; for 66h; Time; Temperature; regioselective reaction; Reactivity;
DOI:10.1016/j.tet.2008.11.045