19957-18-7

Basic information

• Product Name: Phosphonic acid, (4-fluorobenzoyl)-, diethyl ester
• CAS NO: 19957-18-7
• Molecular Formula: C11H14FO4P
• Molecular Weight: 260.202
• Mol File: 19957-18-7.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Phosphonic acid, (4-fluorobenzoyl)-, diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Phosphonic acid, (4-fluorobenzoyl)-, diethyl ester(19957-18-7)
• EPA Substance Registry System: Phosphonic acid, (4-fluorobenzoyl)-, diethyl ester(19957-18-7)

Safety Data

• Hazardous Substances Data: 19957-18-7(Hazardous Substances Data)

Upstream product

• 78-40-0 triethyl phosphate 
• 403-43-0 4-fluorobenzoyl chloride 
• 201230-82-2 carbon monoxide 
• 762-04-9 phosphonic acid diethyl ester 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 352-34-1 4-fluoro-1-iodobenzene 
• 456-22-4 4-Fluorobenzoic acid 
• 122-52-1 triethyl phosphite 

Downstream Products

• 1315552-49-8 (R)-diethyl [1-(4-fluorophenyl)-1-hydroxy-3-oxopropyl]phosphonate 
• 1513846-37-1 diethyl ((2S,3S)-2-(4-fluorophenyl)-5-oxo-3-phenyltetrahydrofuran-2-yl)phosphonate 
• 1402349-97-6 C₁₅H₂₃FNO₄PSi 
• 1293917-95-9 diethyl (2-(4-fluorophenyl)-4-oxo-3,4-dihydro-2H-pyran-2-yl)phosphonate 
• 1123495-95-3 diethyl 3,3,3-trifluoro-1-(4-fluorophenyl)-1-oxo-2-phenylpropan-2-yl phosphate 
• 929900-94-7 diethyl cyano(4-fluorophenyl)(trimethylsilyloxy)methylphosphonate 
• 154109-23-6 [(4-Fluoro-phenyl)-hydroxyamino-methyl]-phosphonic acid diethyl ester 

Relevant articles and documents

Carbene-catalyzed enal γ-carbon addition to α-ketophosphonates for enantioselective access to bioactive 2-pyranylphosphonates

A carbene-catalyzed enantioselective [4+2] cycloaddition reaction between α,β-unsaturated aldehydes and α-ketophosphonates is developed. The reaction affords chiral 2-pyranylphosphonates with excellent enantioselectivities. The optically enriched phosphonate products bear multiple functional groups, including unsaturated lactone and phosphonate moieties that often lead to unique bio-activities. Preliminary studies show that the products from our reactions exhibit anti-bacterial (X. oryzae pv. oryzae) and anti-viral (Tobacco Mosaic Virus) activities for potential use in plant protection.

Synthesis of acylphosphonates by a palladium-catalyzed phosphonocarbonylation reaction of aryl iodides with phosphites

Acylphosphonates are conveniently synthesized from aryl iodides by a palladium-catalyzed reaction with dialkyl phosphites under an atmospheric pressure of carbon monoxide. The reaction demonstrates the first example of the use of phosphorus nucleophiles in related metal-catalyzed carbonylation reactions.

Palladium-catalyzed asymmetric hydrogenation of N-hydroxya-imino phosphonates using bronsted acid as activator: The first catalytic enantioselective approach to chiral N-hydroxy-aamino phosphonates

The enantioselective synthesis of ring-substituted [N-(hydroxy)amino] ACHTUNGTRENUNG(phenyl)methylphos- ACHTUNGTRENUNGphonic esters via asymmetric hydrogenation of the corresponding N-hydroxy-a-imino phosphonates with up to 90% ee was developed using cata