19962-26-6

Basic information

• Product Name: 4-FLUOROBENZYLOXYBENZENE
• Synonyms: 4-FLUOROBENZYLOXYBENZENE
• CAS NO: 19962-26-6
• Molecular Formula: C₁₃H₁₁FO
• Molecular Weight: 202.2242432
• Mol File: 19962-26-6.mol
• Article Data: 7

Chemical Properties

• Melting Point: 45-46°C
• Appearance: /
• CAS DataBase Reference: 4-FLUOROBENZYLOXYBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-FLUOROBENZYLOXYBENZENE(19962-26-6)
• EPA Substance Registry System: 4-FLUOROBENZYLOXYBENZENE(19962-26-6)

Safety Data

• Hazardous Substances Data: 19962-26-6(Hazardous Substances Data)

Upstream product

• 139-02-6 sodium phenoxide 
• 352-11-4 1-chloromethyl-4-fluorobenzene 
• 98-80-6 phenylboronic acid 
• 459-56-3 4-fluorobenzylic alcohol 
• 66003-78-9 triphenylsulfonium trifluoromethanesulfonate 
• 459-46-1 4-Fluorobenzyl bromide 
• 108-95-2 phenol 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 1195931-70-4 C₁₄H₁₁F₃O₄S 
• 459-57-4 4-fluorobenzaldehyde 

Downstream Products

• 459-57-4 4-fluorobenzaldehyde 
• 108-95-2 phenol 
• 6425-41-8 N-cyclohexylmorpholine 
• 141581-12-6 (4-fluorophenyl)(4-hydroxyphenyl)methane 
• 401-30-9 2-(4-fluorobenzyl)phenol 
• 900911-39-9 1-bromo-4-((4-fluorobenzyl)oxy)benzene 
• 56442-14-9 4-((4'-fluoro)benzyloxy)benzonitrile 

Relevant articles and documents

An alternative route for boron phenoxide preparation from arylboronic acid and its application for C[sbnd]O bond formation

An efficient synthetic route to benzyl phenyl ether preparation has been successfully developed via a one-pot synthetic protocol utilizing a combination of arylboronic acids, hydrogen peroxide (H2O2), and benzyl halides. The whole procedure consists of two consecutive reactions, formation of boron phenoxide from arylboronic acids and its nucleophilic attack. A simple operation under mild conditions such as room-temperature ionic liquid (choline hydroxide), aerobic environment, and absence of metal- and base-catalysts has been employed. Expansion to utilize benzyl surrogates was also successfully accomplished.

Metal-Free C-O Bond Functionalization: Catalytic Intramolecular and Intermolecular Benzylation of Arenes

A catalytic, metal-free intramolecular rearrangement of benzyl phenyl ethers using nitrosonium salt as a catalyst is described. The optimized reaction conditions enabled a catalytic and metal-free Friedel-Crafts alkylation reaction with benzylic alcohols, producing water as the stoichiometric byproduct. A comprehensive scope (>50 examples) for both approaches and application in drug synthesis were demonstrated. Mechanistic studies suggest a Lewis acid-based mechanism for the metal-free Friedel-Crafts reaction.

Formation of arf from lpdar(f): catalytic conversion of aryl triflates to aryl fluorides

Despite increasing pharmaceutical importance, fluorinated aromatic organic molecules remain difficult to synthesize. Present methods require either harsh reaction conditions or highly specialized reagents, making the preparation of complex fluoroarenes ch