1997-41-7

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
5-(TRIFLUOROMETHYL)ISOINDOLINE-1,3-DIONE is used as a building block in the synthesis of pharmaceuticals and agrochemicals due to its unique structural and chemical properties.
Used in Organic Synthesis and Medicinal Chemistry:
5-(TRIFLUOROMETHYL)ISOINDOLINE-1,3-DIONE is used as a reagent in organic synthesis and medicinal chemistry for the preparation of diverse bioactive molecules.
Used in Material Science:
5-(TRIFLUOROMETHYL)ISOINDOLINE-1,3-DIONE has been studied for its potential applications in material science, such as in the development of novel polymers and molecular devices for electronic and optoelectronic applications.

InChI:InChI=1/C9H4F3NO2/c10-9(11,12)4-1-2-5-6(3-4)8(15)13-7(5)14/h1-3H,(H,13,14,15)

Upstream product

• 26238-14-2 5-trifluoromethylbenzofuran-1,3-dione 
• 657-06-7 2-chloro-5-trifluoromethylbenzoic acid 
• 544-92-3 copper(I) cyanide 
• 835-58-5 4-(trifluoromethyl)phthalic acid 
• 78164-31-5 1,2-dimethyl-4-(trifluoromethyl)benzene 

Downstream Products

• 20036-05-9 4-trifluoromethylphthalamide 
• 1483-45-0 4-trifluoromethylphthalodinitrile 
• 342638-03-3 5-trifluoromethyl-2,3-dihydro-1H-isoindole 
• 204069-83-0 (3-Chloro-4-methoxy-benzyl)-(4-chloro-7-trifluoromethyl-phthalazin-1-yl)-amine 
• 20036-02-6 4-Trifluormethyl-phthalsaeure-monoamid 

Relevant academic research and scientific papers

Inhibitors of dipeptidyl peptidase 8 and dipeptidyl peptidase 9. Part 2: Isoindoline containing inhibitors

To obtain selective and potent inhibitors of dipeptidyl peptidases 8 and 9, we synthesized a series of substituted isoindolines as modified analogs of allo-Ile-isoindoline, the reference DPP8/9 inhibitor. The influence of phenyl substituents and different P2 residues on the inhibitors' affinity toward other DPPs and more specifically, their potential to discriminate between DPP8 and DPP9 will be discussed. Within this series compound 8j was shown to be a potent and selective inhibitor of DPP8/9 with low activity toward DPP II.

4-Benzylamino-1-chloro-6-substituted phthalazines: Synthesis and inhibitory activity toward phosphodiesterase 5

We synthesized various 4-benzylamino-1-chloro-6-substituted phthalazines (15) and 4-benzylamino-1-chloro-7-substituted phthalazines (16) and evaluated their inhibitory activity toward phosphodiesterase 5 (PDE5) purified from porcine platelets. The PDE5-inhibitory activities of 15 were greater than those of the isomers (16). The preferred substituent at the 4-position of phthalazine was a (3-chloro-4-methoxybenzyl)amino group, and those at the 6- position were cyano, nitro, and trifluoromethyl groups. Compounds 15a (IC50 = 4.8 nM), 15f (3.5 nM), and 15i (5.3 nM) were more potent inhibitors than E4021 (8.6 nM). Compounds 15a and 15f also showed vasorelaxant activity in isolated porcine coronary arteries precontracted with prostaglandin F(2α) (10-5 M). The EC50 values for vasorelaxant action of 15a, 15f, and E4021 were 150, 160, and 980 nM, respectively. These results show that novel PDE5 inhibitors possessing a potent vasorelaxant effect may exist among phthalazine derivatives.