19978-25-7

Usage

Physical properties

yellow crystalline solid

Uses

synthesis of pharmaceuticals and dyes, intermediate in organic synthesis, reagent in biochemical research

Studied properties

potential antimicrobial and antioxidant properties

Hazards

considered hazardous due to toxicity and potential environmental impact

Upstream product

• 6307-90-0 3,4,5-trimethoxy-1-nitrobenzene 
• 118-41-2 Eudesmic acid 
• 91-10-1 1,3-dimethoxy-2-hydroxy-benzene 
• 634-36-6 1,2,3-trimethoxybenzene 
• 530-57-4 3,5-dimethoxy-4-hydroxybenzoic acid 

Downstream Products

• 176915-25-6 Carbonic acid benzyl ester 2,6-dimethoxy-4-nitro-phenyl ester 
• 957420-26-7 ethyl 2-(2,6-dimethoxy-4-nitrophenoxy)acetate 
• 957420-37-0 2-[(2,6-dimethoxy-4-nitrophenoxy)methyl]-1,3-dioxolane 
• 700805-14-7 3,5-dimethoxy-4-(2-morpholin-4-ylethoxy)aniline 
• 1015077-04-9 4-[2-(2,6-dimethoxy-4-nitro-phenoxy)-ethyl]-morpholine 
• 835633-53-9 3,5-dimethoxy-4-(2-(4-methylpiperazin-1-yl)ethoxy)aniline 
• 1015077-03-8 1-[2-(2,6-dimethoxy-4-nitro-phenoxy)-ethyl]-4-methyl-piperazine 
• 835633-54-0 3,5-dimethoxy-4-(3-(4-methylpiperazin-1-yl)propoxy)aniline 
• 1015077-07-2 1-[3-(2,6-dimethoxy-4-nitro-phenoxy)-propyl]-4-methyl-piperazine 
• 176915-27-8 Carbonic acid 4-amino-2,6-dimethoxy-phenyl ester benzyl ester 
• 176915-14-3 (5R,11R,11aS)-4,5,11,11a-tetrahydro-5-[3,5-dimethoxy-4-(carbobenzoxyoxy)phenyl]-11-[3,5-dimethoxy-4-(carbobenzoxyoxy)anilino]-1H,6H-oxazolo[3',4':1,6]pyrido[3,4-b]indol-3-one 
• 15834-60-3 4-hydroxy-3,5-dimethoxyaniline 

Relevant academic research and scientific papers

SUBSTITUTED TRIAZINE COMPOUNDS AND USES THEREOF

The present invention relates to compounds of formula (I) : including any stereochemically isomeric form thereof, or pharmaceutically acceptable salts thereof, for the treatment of, for example, hypercholesterolemia.

Compound targeting FAK and marker thereof as well as preparation method and application thereof (by machine translation)

The invention provides a compound targeting FAK, the structure of which is shown by the following formula (I), wherein R is represented by the following formula (I). 1 - F, Cl, Br, CH3 OR-OCH3 ; R2 , R3/su

Design, synthesis, and biological evaluation of F-18-labelled 2, 4-diaminopyrimidine-type FAK-targeted inhibitors as potential tumour imaging agents

As a type of intracellular nonreceptor tyrosine kinase, focal adhesion kinase (FAK) can be highly expressed in most types of tumours and is thus regarded as a promising antitumour target. In this study, a series of novel 2,4-diaminopyrimidine FAK-targeted

Iodine(III)-Catalyzed Electrophilic Nitration of Phenols via Non-Br?nsted Acidic NO2+ Generation

The first catalytic procedure for the electrophilic nitration of phenols was developed using iodosylbenzene as an organocatalyst based on iodine(III) and aluminum nitrate as a nitro group source. This atom-economic protocol occurs under mild, non-Br?nsted acidic and open-flask reaction conditions with a broad functional-group tolerance including several heterocycles. Density functional theory (DFT) calculations at the (SMD:MeCN)Mo8-HX/(LANLo8+f,6-311+G) level indicated that the reaction proceeds through a cationic pathway that efficiently generates the NO2+ ion, which is the nitrating species under neutral conditions.

IRAK DEGRADERS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

Pharmacophore Hybridization to Discover Novel Topoisomerase II Poisons with Promising Antiproliferative Activity

We used a pharmacophore hybridization strategy to combine key structural elements of merbarone and etoposide and generated new type II topoisomerase (topoII) poisons. This first set of hybrid topoII poisons shows promising antiproliferative activity on hu

5-CARBOXAMIDE-2-THIOBARBITURIC ACIDS AND USE THEREOF AS MEDICAMENTS

The invention relates to a class of 5-carboxamide-2-thiobarbituric acid derivatives which inhibits human type II topoisomerase (topoII) enzyme and to use thereof as medicaments especially for blocking the proliferation of cancer cells and treating cancer.

Chemoselective nitration of phenols with iert-butyl nitrite in solution and on solid support

test-Butyl nitrite was identified as a safe and chemoselective nitrating agent that provides preferentially mononltro derivatives of phenolic substrates In the presence of potentially competitive functional groups. On the basis of our control experiments, we propose that the reaction proceeds through the formation of O-nltrosyl Intermediates prior to C-nitration via homolysis and oxidation. The reported nitration method Is compatible with tyroslne-containlng peptides on solid support In the synthesis of fluorogenic substrates for characterization of proteases.

Inhibition of DNA topoisomerase II by azaelliptitoxins functionalized in the variable substituent domain

A series of novel C11-substituted derivatives of azaelliptitoxin (azatoxin) have been synthesized and tested for their inhibitory activity against human DNA topoisomerase II. Incorporation of a C11 polyamine or amine resulted in an i

Boron Trichloride as a Selective Demethylating Agent for Hindered Ethers: a Synthesis of the Phytoalexins α- and β-Pyrufuran, a Synthesis of Tri-O-methylleprolomin and its Demethylation

Boron trichloride has been found to be an efficient reagent for the selective cleavage of sterically hindered methoxy groups in methoxyarenes.The scope and utility of this reaction are explored with examples drawn from derivatives of benzene, naphtalene, 9,10-dihydrophenanthrene and dibenzofuran.The method is applied to the synthesis of the phytoalexins α- (56) and β-pyrofuran (58) (1,3,4-trimethoxydibenzofuran-2-ol and 1,2,4-trimethoxydibenzofuran-3-ol).A synthesis of tri-O-methylleprolomin (61), a derivative of the unusual lichen metabolite leprolomin (60), is described and its demethylation with boron trichloride is studied.