6307-90-0

Usage

Uses

Used in Pharmaceutical Industry:
1,2,3-Trimethoxy-5-nitrobenzene is used as a key intermediate for the synthesis of various pharmaceutical drugs. Its unique chemical structure allows it to be a valuable building block in the development of new medications, contributing to the advancement of healthcare and treatment options.
Used in Dye and Pigment Industry:
In the dye and pigment industry, 1,2,3-trimethoxy-5-nitrobenzene is utilized as an intermediate in the production of a range of dyes and pigments. Its chemical properties make it suitable for creating vibrant and stable colorants used in various applications, including textiles, plastics, and printing inks.
Used in Organic Synthesis:
1,2,3-Trimethoxy-5-nitrobenzene is employed as a reagent in organic synthesis, where it serves as a starting material for the preparation of a variety of organic compounds. Its versatility in chemical reactions makes it an essential component in the synthesis of complex organic molecules, contributing to the development of new materials and chemical processes.
Used in Research and Development:
In the field of research and development, 1,2,3-trimethoxy-5-nitrobenzene is used as a compound of interest for studying its properties and potential applications. Its unique structure and reactivity make it a valuable subject for scientific investigation, leading to a deeper understanding of organic chemistry and the discovery of new applications for 1,2,3-TRIMETHOXY-5-NITROBENZENE.

InChI:InChI=1/C9H11NO5/c1-13-7-4-6(10(11)12)5-8(14-2)9(7)15-3/h4-5H,1-3H3

Upstream product

• 1136-86-3 methyl (3,4,5-trimethoxyphenyl) ketone 
• 118-41-2 Eudesmic acid 
• 7697-37-2 nitric acid 
• 64-19-7 acetic acid 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 32905-18-3 5-Nitropyrogallol-1,3-dibenzolsulfonat-2-methylaether 
• 32905-27-4 5-Nitropyrogallol-1,3-dibenzolsulfonat 
• 32905-21-8 2,3-dimethoxy-5-nitrophenyl benzenesulfonate 
• 32905-22-9 5-Nitro-pyrogallol-1-benzolsulfonat-2-methylaether 
• 55020-69-4 2,6-bis-benzenesulfonyloxy-phenol 
• 1885-35-4 3,4,5-trimethoxybenzonitrile 
• 3086-62-2 3,4,5-trimethoxybenzamide 
• 634-36-6 1,2,3-trimethoxybenzene 
• 32905-09-2 2,3-dimethoxy-5-nitrophenol 

Downstream Products

• 14416-24-1 3,4,5-trihydroxy-1-nitrobenzene 
• 860518-52-1 1,2,3-trimethoxy-4,5-dinitro-benzene 
• 68560-20-3 2-bromo-3,4,5-trimethoxy-1-nitro-benzene 
• 860556-74-7 2-chloro-3,4,5-trimethoxy-1-nitro-benzene 
• 108130-17-2 1,3-dichloro-4,5,6-trimethoxy-2-nitro-benzene 
• 99512-65-9 1,3-dibromo-4,5,6-trimethoxy-2-nitro-benzene 
• 24313-88-0 3,4,5-Trimethoxyaniline 
• 22867-29-4 2,6-dimethoxy-1,4-benzoquinone-4-oxime 
• 189564-60-1 3,5-dimethoxy-4-ethoxynitrobenzene 
• 319492-60-9 2-tert-butoxy-1,3-dimethoxy-5-nitro-benzene 
• 319492-58-5 2-butoxy-1,3-dimethoxy-5-nitro-benzene 
• 19978-25-7 3,5-dimethoxy-4-hydroxynitrobenzene 

Relevant academic research and scientific papers

Compound targeting FAK and marker thereof as well as preparation method and application thereof (by machine translation)

The invention provides a compound targeting FAK, the structure of which is shown by the following formula (I), wherein R is represented by the following formula (I). 1 - F, Cl, Br, CH3 OR-OCH3 ; R2 , R3/su

Design, synthesis, and biological evaluation of F-18-labelled 2, 4-diaminopyrimidine-type FAK-targeted inhibitors as potential tumour imaging agents

As a type of intracellular nonreceptor tyrosine kinase, focal adhesion kinase (FAK) can be highly expressed in most types of tumours and is thus regarded as a promising antitumour target. In this study, a series of novel 2,4-diaminopyrimidine FAK-targeted

Modular synthesis of polymers containing 2,5-di(thiophenyl)-N-arylpyrrole

A modular and facile route has been developed to synthesize functionalized 2,5-di(thiophen-2-yl)-1-H-arylpyrroles from readily available starting materials. These units are compatible with various polymerization conditions and are versatile building blocks for conjugated polymers. The polymers show high thermal stability and solubility in a number of solvents. Characterization of the polymers reveals a correlation between molecular packing, controllable by polymer design, and charge carrier mobility.

Synthesis of nitroolefins and nitroarenes under mild conditions

1,3-Disulfonic acid imidazolium nitrate {[Dsim]NO3} was prepared and characterized as a new ionic liquid and nitrating agent for the ipso-nitration of various arylboronic acids and nitro-Hunsdiecker reaction of different α,β-unsaturated acids and benzoic acid derivatives, by in situ generation of NO2 to give various nitroarenes and nitroolefins without using any cocatalysts and solvents under mild conditions.

Screening Libraries of Semifluorinated Arylene Bisimides to Discover and Predict Thermodynamically Controlled Helical Crystallization

Synthesis, structural, and retrostructural analysis of a library containing 16 self-assembling perylene (PBI), 1,6,7,12-tetrachloroperylene (Cl4PBI), naphthalene (NBI), and pyromellitic (PMBI) bisimides functionalized with environmentally friendly AB3 chiral racemic semifluorinated minidendrons at their imide groups via m = 0, 1, 2, and 3 methylene units is reported. These semifluorinated compounds melt at lower temperatures than homologous hydrogenated compounds, permitting screening of all their thermotropic phases via structural analysis to discover thermodynamically controlled helical crystallization from propeller-like, cogwheel, and tilted molecules as well as lamellar-like structures. Thermodynamically controlled helical crystallization was discovered for propeller-like PBI, Cl4PBI and NBI with m = 0. Unexpectedly, assemblies of twisted Cl4PBIs exhibit higher order than those of planar PBIs. PBI with m = 1, 2, and 3 form a thermodynamically controlled columnar hexagonal 2D lattice of tilted helical columns with intracolumnar order. PBI and Cl4PBI with m = 1 crystallize via a recently discovered helical cogwheel mechanism, while NBI and PMBI with m = 1 form tilted helical columns. PBI, NBI and PMBI with m = 2 generate lamellar-like structures. 3D and 2D assemblies of PBI with m = 1, 2, and 3, NBI with m = 1 and PMBI with m = 2 exhibit 3.4 ? π-π stacking. The library approach applied here and in previous work enabled the discovery of six assemblies which self-organize via thermodynamic control into 3D and 2D periodic arrays, and provides molecular principles to predict the supramolecular structure of electronically active components.

Supramolecular assembly of isocyanorhodium(i) complexes: An interplay of rhodium(i)···rhodium(i) interactions, hydrophobic-hydrophobic interactions, and host-guest chemistry

A series of tetrakis(isocyano)rhodium(I) complexes with different chain lengths of alkyl substituents has been found to exhibit a strong tendency toward solution state aggregation upon altering the concentration, temperature and solvent composition. Temperature- and solvent-dependent UV-vis absorption studies have been performed, and the data have been analyzed using the aggregation model to elucidate the growth mechanism. The aggregation is found to involve extensive Rh(I)···Rh(I) interactions that are synergistically assisted by hydrophobic-hydrophobic interactions to give a rainbow array of solution aggregate colors. It is noted that the presence of three long alkyl substituents is crucial for the observed cooperativity in the aggregation. Molecular assemblies in the form of nanoplates and nanovesicles have been observed in the hexane-dichloromethane solvent mixtures, arising from the different formation mechanisms based on the alkyl chain length of the complexes. Benzo-15-crown-5 moieties have been incorporated for selective potassium ion binding to induce dimer formation and drastic color changes, rendering the system as potential colorimetric and luminescent cation sensors and as building blocks for ion-controlled supramolecular assembly.

Synthesis and biological evaluation of 3-alkyl-1,5-diaryl-1H-pyrazoles as rigid analogues of combretastatin A-4 with potent antiproliferative activity

A series of novel 3-alkyl-1,5-diaryl-1H-pyrazoles were synthesized as combretastatin A-4 (CA-4) analogues and evaluated for antiproliferative activity against three human cancer cell lines (SGC-7901, A549 and HT-1080). Most of the target compounds displayed moderate to potent antiproliferative activity, and 7k was found to be the most potent compound. Structure-activity relationships indicated that compounds with a trimethoxyphenyl A-ring at the N-1 position of the pyrazole skeleton were more potent than those with the A-ring at the C-5 position. Tubulin polymerization and immunostaining experiments revealed that 7k potently inhibited tubulin polymerization and disrupted tubulin microtubule dynamics in a manner similar to CA-4. Computational modelling demonstrated that the binding of 7k to the colchicine binding site on microtubules may involve a similar mode as CA-4.

Synthesis of novel supramolecular triads bearing a H-bonded perylene bisimide core

Two novel hydrogen-bonded (H-bonded) triads consisting of triazine derivatives complexed with a perylene bisimide core were synthesized and characterized. NMR, UV/vis, and fluorescence spectra of these supramolecular triads confirmed the formation of stro

2,4-DIAMINO-6,7-DIHYDRO-5H-PYRROLO[2,3]PYRIMIDINE DERIVATIVES AS FAK/Pyk2 INHIBITORS

The invention relates to a novel class of 2,4-diamino-6,7-dihydro-5H-pyrrolo[2,3]pyrimidine derivatives as a FAK and/or Pyk2 inhibitor, to a process for their preparation, and to a composition thereof, as well as to use of the compounds for the inhibiting FAK and/or Pyk2 and method for the treatment of a FAK and/ or Pyk2 mediated disorder or disease.

Preparation of two sets of 5,6,7-trioxygenated dihydroflavonol derivatives as free radical scavengers and neuronal cell protectors to oxidative damage

An unusual class of 5,6,7-trioxygenated dihydroflavonols (3a-e and 4a-j) were designed and prepared. Their antioxidative properties were assessed by examining their capacities in several in vitro models, including superoxide anion and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, rat liver homogenate lipid peroxidation inhibition, PC12 cells protection from oxidative damage, and xanthine oxidase inhibition. These dihydroflavonols displayed positive quenching abilities towards O2{radical dot} - and DPPH free radicals, in which the majority exhibited superior antioxidant properties to Vitamin C. cis-Configurated compound (±)-3e demonstrated remarkable inhibition to LPO with an IC50 value of 1.9 ± 0.3 μM, which was apparently stronger than that of quercetin (IC50 = 6.0 ± 0.4 μM). trans-Configurated dihydroflavonol (±)-4h exhibited significant protective effect on PC12 cells against oxidative damage with an EC50 value of 41.5 ± 5.3 μM, more effective compared to that of quercetin (EC50 = 81.8 ± 8.7 μM). The 6-OH-5,7-dimethoxy analogue (±)-3d showed significant inhibition of xanthine oxidase with an IC50 value of 16.0 ± 0.8 μM, which is superior to that of allopurinol (IC50 = 23.5 ± 2.0 μM). In addition to the hypothesized action mechanism of the bio-active compounds, 3D modeling was used to analyze the relationship between the minimized-energy structures and antioxidant activities.