199784-03-7Relevant academic research and scientific papers
Carbohydrate sulfonyl chlorides for simple, convenient access to glycoconjugates
Kvaerno, Lisbet,Werder, Moritz,Hauser, Helmut,Carreira, Erick M.
, p. 1145 - 1148 (2007/10/03)
(Chemical Equation Presented) The use of carbohydrate sulfonyl chlorides is introduced as a new, facile glycoconjugation method which could find broad applications. We demonstrate the approach by synthesizing a number of glycosylated cholesterol absorptio
Synthesis and in vitro evaluation of inhibitors of intestinal cholesterol absorption
Kv?rn?, Lisbet,Werder, Moritz,Hauser, Helmut,Carreira, Erick M.
, p. 6035 - 6053 (2007/10/03)
We have utilized our recently developed in vitro assay to address two key questions in the design of small-molecule cholesterol absorption inhibitors using ezetimibe, the only drug yet approved for the inhibition of cholesterol absorption in the small int
Studies on the synthesis of C-glycoside sulfones as potential glycosyl transferase inhibitors
Gervay, Jacquelyn,Flaherty, Terrence M.,Holmes, Daniel
, p. 16355 - 16364 (2007/10/03)
β-C-Glycoside sulfoxides and sulfones were prepared by radical addition of thiol acetic acid to exocyclic glycals followed by deacetylation, S-alkylation, and selective oxidation. These compounds are representative examples of a new class of molecules designed to be glycosyl transferase inhibitors.
