199791-16-7Relevant academic research and scientific papers
Understanding difficulties of irregular number-membered ring transition states for intramolecular proton transfer in excited state
Qin, Xiaozhuan,Ding, Ge,Wang, Zhenqiang,Gong, Yulong,Gao, Fang,Zhang, Shengtao,Luo, Ziping,Li, Hongru
, p. 403 - 410 (2017/01/03)
This study presents a variety of organic dyes with similar molecular structures that could undergo intramolecular proton transfer in excited states via five-, six- and seven-number-membered ring transition states, respectively. In addition, the dyes without proton transfer segments are also synthesized to use as references. X-ray single crystal diffraction, NMR spectra as well as UV/visible spectra suggests the presence of internal hydrogen bond with different strength in the target dyes. The steady and transient fluorescence measurements demonstrate occurrence of excited state intramolecular proton transfer via a six number-membered ring transition state. In contrast, it cannot be processed through five- and seven-number-membered ring transition states of the studied dyes. The molecular geometry optimization of the studied dyes reveals fundamental factors for the difficulties of intramolecular proton transfer in excited states via five- and seven-number-membered ring transition states.
A small molecule that displays marked reactivity toward copper-versus zinc-amyloid-β implicated in Alzheimer's disease
Savelieff, Masha G.,Liu, Yuzhong,Senthamarai, Russell R.P.,Korshavn, Kyle J.,Lee, Hyuck Jin,Ramamoorthy, Ayyalusamy,Lim, Mi Hee
supporting information, p. 5301 - 5303 (2014/05/06)
Alzheimer's disease (AD) is a complex, multifactorial, neurodegenerative disease that poses tremendous difficulties in pinpointing its precise etiology. A toolkit, which specifically targets and modulates suggested key players, may elucidate their roles i
Synthesis of 3-Substitued Benzoxazoline-2-thiones
Yamato, Masatoshi,Takeuchi, Yasuo,Hashigaki, Kuniko,Hattori, Kyoko,Muroga, Eiko,Hirota, Takashi
, p. 1733 - 1737 (2007/10/02)
Several methods for the preparation of 3-substitued benzoxazoline-2-hiones (1) were examined.Method B via the thiation of 3-substitued benzoxazoline-2-one (5) with phosphorus pentasulfide was found to be applicable to the preparation of most analogs of 1, with a few expections.Method C via the cyclization of 2-(alkylamino)phenol (7) with potassium O-methyldithiocarbonate was suitable for the preparation of analogs with a group sensitive to high temperature of with an aryl- (including aromatic heterocyclic ring) methyl group.In addition, the reaction of benzoxazoline-2-thione (2) with acetals such as 1-ethoxyisochroman, 2-ethoxytetrahydrofuran, and ethoxytetraydropyran, or with Michael acceptors such as 2,3-dihydrofuran and 2H-3,4-dihydropyran, gave 3-substitued benzoxazoline-2-thione (1d-f).
