19988-98-8

Basic information

• Product Name: [1,2,4]Triazolo[4,3-a]quinoxaline, 1,4-diphenyl-
• CAS NO: 19988-98-8
• Molecular Formula: C21H14N4
• Molecular Weight: 322.369
• Mol File: 19988-98-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: [1,2,4]Triazolo[4,3-a]quinoxaline, 1,4-diphenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: [1,2,4]Triazolo[4,3-a]quinoxaline, 1,4-diphenyl-(19988-98-8)
• EPA Substance Registry System: [1,2,4]Triazolo[4,3-a]quinoxaline, 1,4-diphenyl-(19988-98-8)

Safety Data

• Hazardous Substances Data: 19988-98-8(Hazardous Substances Data)

Upstream product

• 1504-78-5 2-hydroxy-3-phenylquinoxaline 
• 1025-22-5 2-hydrazino-3-phenylquinoxaline 
• 65-85-0 benzoic acid 
• 120-46-7 1,3-diphenylpropanedione 
• 100-52-7 benzaldehyde 
• 1049-25-8 2-(N'-benzylidenehydrazino)-3-phenylquinoxaline 
• 95-54-5 1,2-diamino-benzene 
• 88-74-4 2-nitro-aniline 

Relevant articles and documents

1,2,4-triazole derivative having quinoxaline structure, preparation method and application thereof

The invention discloses a 1,2,4-triazole derivative having quinoxaline structure, a preparation method and an application thereof. O-nitroaniline and hydrazine hydrate react to form a compound (II). The compound (II) reacts with MBF to prepare a compound

A reinvestigation of reaction of 2-hydrazino-3-phenylquinoxaline with 1,3-diketones: Synthesis and characterization of regioisomeric 1-(3′-phenylquinoxalin-2′-yl)-3,5-disubstitutedpyrazoles and 1,2,4-triazolo[4,3-a]quinoxalines

A reinvestigation into the reaction of 2-hydrazino-3-phenylquinoxaline 1 with several 1,3-diketones 2a-g reveals that a mixture of regioisomeric 1-(3′-phenylquinoxalin-2′-yl)-3,5-disubstitutedpyrazoles 3a-g and 4a-e and 1-methyl-4-phenyl/methyl-1,2,4-triazolo[4,3-a]quinoxalines 5a,b is formed as reaction products rather than erroneously reported exclusive formation of triazole 5 in case of aryl alkyl-1,3-diketones or 1-(3′- phenylquinoxalin-2′-yl)-3-alkylpyrazoles 4 in case of dialkyl and diaryl-1,3-diketones. Structural elucidation of the regioisomeric pyrazoles has been established by the spectroscopic data (1H, 13C NMR, COSY experiments and HRMS) and minimum energy 3-D diagrams.

Quinoxaline derivatives part II: Synthesis and antimicrobial testing of 1,2,4-triazolo[4,3-a]quinoxalines, 1,2,4-triazino[4,3-a]quinoxalines and 2- pyrazolylquinoxalines

Three main classes of quinoxaline derivatives have been synthesized. The first class comprises the synthesis of three novel series of 1,2,4- triazolo[4,3-a]quinoxalines; namely 1-substituted-1,2,4-triazolo[4,3- a]quinoxalines 3a-f, 1-substituted aminomethyl-1,2,4-triazolo[4,3- a]quinoxalines 14a-d and 1-cyano or ethoxycarbonylmethyl-1,2,4- triazolo[4,3a]quinoxalines 6, 12. The second class involves the synthesis of 2-substituted-1H-1,2,4-triazino[4,3-a]quinoxalines 4a-d. The third class deals with the synthesis of a variety of 2-pyrazolylquinoxalines, namely 2- (5-amino-3-arylpyrazol-1-yl)-3-phenylquinoxalines 5a-d, 2-[5-hydroxy-3- phenyl-4-(4-substituted sulfamoylphenyl)azopyrazol-1-yl]-3-phenylquinoxalines 15a, b, and 2-(5-hydroxy-4-nitroso-3-phenylpyrazol-1-yl)-3-phenylquinoxaline (16). The prepared compounds were tested in vitro for their antimicrobial activity. Compounds 13 and 14b exhibited promising antifungal activity against C. albicans (MIC 25, 50 μ/ml respectively). Compound 13 was as active as the antibiotic nystatin.