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2,2-dimethylchroman-6-amine, also known as troloxamine, is a chemical compound belonging to the class of chroman amines. It is a derivative of vitamin E, characterized by its antioxidant properties. Troloxamine is recognized for its anti-inflammatory and anti-cancer properties, positioning it as a potential candidate for the development of new drugs. Its capacity to protect against oxidative stress and neurodegenerative diseases further underscores its value in medical, biochemistry, and pharmacological research.

19989-18-5

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19989-18-5 Usage

Uses

Used in Pharmaceutical Applications:
2,2-dimethylchroman-6-amine is used as a pharmaceutical agent for its antioxidant properties, which contribute to the prevention of oxidative stress and the mitigation of neurodegenerative diseases. Its anti-inflammatory and anti-cancer properties make it a promising candidate for the development of new drugs targeting various pathologies.
Used in Cosmetic Applications:
In the cosmetic industry, 2,2-dimethylchroman-6-amine is used as an ingredient for its antioxidant capabilities, helping to protect the skin from environmental stressors and promoting overall skin health.
Used in Research:
2,2-dimethylchroman-6-amine is utilized as a research compound in the fields of medicine, biochemistry, and pharmacology, where its chemical structure and properties are studied to advance understanding of its potential therapeutic applications and mechanisms of action.

Check Digit Verification of cas no

The CAS Registry Mumber 19989-18-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,9,9,8 and 9 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 19989-18:
(7*1)+(6*9)+(5*9)+(4*8)+(3*9)+(2*1)+(1*8)=175
175 % 10 = 5
So 19989-18-5 is a valid CAS Registry Number.

19989-18-5Relevant academic research and scientific papers

Synthesis and evaluation of 2,2-dimethylchroman derivatives as inhibitors of ICAM-1 expression on human endothelial cells

Dhawan, Ashish,Balwani, Sakshi,Prasad, Ashok K.,Ghosh, Balaram,Parmar, Virinder S.

, p. 1712 - 1719 (2015/01/09)

We herein report the synthesis of novel 2,2-dimethylchroman analogs and their effect on the modulation of tumor necrosis factor-α-induced expression of intercellular adhesion molecule-1 in human endothelial cells. These compounds were found to be potent i

PROCESS FOR PRODUCING AMINOBENZOPYRAN COMPOUND

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Page/Page column 8-9, (2008/06/13)

There is provided a method for producing aminobenzopyran compound, which results in little wastes, has no influence on reactors and necessitates a simple work-up procedure. Concretely, it is a method for producing aminobenzopyran compound of formula (2)characterized by reducing a nitro group on 2,2-dimethyl 2H-1-benzopyran compound of formula (1) with hydrazine in the presence of a metal catalyst.

Synthesis and Antimicrobial Activity of Some 2-Amino-4-aryl-5-chromanylazothiazoles

Ahluwalia, V. K.,Singh, Raj P.,Singh, Rishi P.

, p. 287 - 289 (2007/10/02)

The title compounds have been synthesised by the condensation of diazotised 6-amino-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran with different 2-amino-4-arylthiazoles which in turn have been prepared by cyclocondensation of acetophenones with thiourea in the

Nuclear Isoprenylation of Aminophenols: Synthesis of Aminosubstituted 3,4-Dihydro-2,2-dimethyl-2H-1-benzopyrans

Ahluwalia, V. K.,Arora, K. K.,Anand, Saroj

, p. 129 - 131 (2007/10/02)

Nuclear isoprenylation of p-aminophenol with isoprene or 2-methylbut-3-en-2-ol in the presence of orthophosphoric acid gives 6-amino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran (1).However, the reaction of p-aminophenol with 2-methylbut-3-en-2-ol in the presence of aqueous citric acid affords 4-amino-2-(3',3'-dimethylallyl)phenol (2).Similar condensation of m-aminophenol with isoprene or 2-methylbut-3-en-2-ol gives a mixture (1:4) of 5-amino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran (3) and 7-amino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran (4).The above condensation in the presence of aqueous citric acid, however gives only 5-amino-2-(3',3'-dimethylallyl)phenol (5).

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