19989-18-5Relevant academic research and scientific papers
Synthesis and evaluation of 2,2-dimethylchroman derivatives as inhibitors of ICAM-1 expression on human endothelial cells
Dhawan, Ashish,Balwani, Sakshi,Prasad, Ashok K.,Ghosh, Balaram,Parmar, Virinder S.
, p. 1712 - 1719 (2015/01/09)
We herein report the synthesis of novel 2,2-dimethylchroman analogs and their effect on the modulation of tumor necrosis factor-α-induced expression of intercellular adhesion molecule-1 in human endothelial cells. These compounds were found to be potent i
PROCESS FOR PRODUCING AMINOBENZOPYRAN COMPOUND
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Page/Page column 8-9, (2008/06/13)
There is provided a method for producing aminobenzopyran compound, which results in little wastes, has no influence on reactors and necessitates a simple work-up procedure. Concretely, it is a method for producing aminobenzopyran compound of formula (2)characterized by reducing a nitro group on 2,2-dimethyl 2H-1-benzopyran compound of formula (1) with hydrazine in the presence of a metal catalyst.
Synthesis and Antimicrobial Activity of Some 2-Amino-4-aryl-5-chromanylazothiazoles
Ahluwalia, V. K.,Singh, Raj P.,Singh, Rishi P.
, p. 287 - 289 (2007/10/02)
The title compounds have been synthesised by the condensation of diazotised 6-amino-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran with different 2-amino-4-arylthiazoles which in turn have been prepared by cyclocondensation of acetophenones with thiourea in the
Nuclear Isoprenylation of Aminophenols: Synthesis of Aminosubstituted 3,4-Dihydro-2,2-dimethyl-2H-1-benzopyrans
Ahluwalia, V. K.,Arora, K. K.,Anand, Saroj
, p. 129 - 131 (2007/10/02)
Nuclear isoprenylation of p-aminophenol with isoprene or 2-methylbut-3-en-2-ol in the presence of orthophosphoric acid gives 6-amino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran (1).However, the reaction of p-aminophenol with 2-methylbut-3-en-2-ol in the presence of aqueous citric acid affords 4-amino-2-(3',3'-dimethylallyl)phenol (2).Similar condensation of m-aminophenol with isoprene or 2-methylbut-3-en-2-ol gives a mixture (1:4) of 5-amino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran (3) and 7-amino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran (4).The above condensation in the presence of aqueous citric acid, however gives only 5-amino-2-(3',3'-dimethylallyl)phenol (5).
