19989-69-6

Upstream product

• 77333-68-7 2-phenylbenzo[d]thiazole-6-carbonitrile 
• 14543-45-4 4-amino-3-mercaptobenzoic acid 
• 98-88-4 benzoyl chloride 
• 100-52-7 benzaldehyde 
• 99073-88-8 ethyl 2-bromo-1,3-benzothiazole-6-carboxylate 
• 98-80-6 phenylboronic acid 
• 582-80-9 p-benzamidobenzoic acid 
• 10205-58-0 6-methyl-2-phenyl-1,3-benzothiazole 
• 19989-70-9 ethyl 2-phenylbenzo[d]thiazole-6-carboxylate 

Relevant academic research and scientific papers

Method used for rapid preparation of benzo-heterocycle compound with physical grinding under solvent-free room temperature conditions

The invention discloses a method used for rapid preparation of benzo-heterocycle compound with physical grinding under solvent-free room temperature conditions. According to the method, glacial aceticacid is taken as a catalyst; at solvent-free room temperature conditions, physical grinding is adopted, reaction of 2-substituted arylamines (2-mercapto arylamine, 2-aminophenol, and o-phenylenediamine) and aromatic aldehydes is carried out using physical grinding. The method is friendly to the environment, is simple in operation, is safe, is low in cost, and is high in efficiency. Compared withthe prior art, the advantages are that: the method is suitable for a large amount of functional groups, yield is high, less by-product is generated, operation is simple, the method is safe, cost is low, and the method is friendly to the environment.

DI-AZETIDINYL DIAMIDE AS MONOACYLGLYCEROL LIPASE INHIBITORS

Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein Q and Z are defined herein.

OXOPIPERAZINE-AZETIDINE AMIDES AND OXODIAZEPINE-AZETIDINE AMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS

Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds, and enantiomers, diastereomers, and pharmaceutically acceptable salts thereof, are represented by Formula (Ia) and Formula (Ib) as follows: wherein Y, Z, and n are defined herein; and wherein Yb and Zb are as defined herein.

AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS

Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I), wherein Y, Z, R1, and s are defined herein.

Microwave-assisted syntheses of 2-phenylbenzothiazoles

A new and easy synthetic route to 2-phenylbenzothiazoles has been achieved by direct thiation of benzoyl derivatives of aniline, various substituted anilines, and 1-naphthylamine under microwave irradiation. The oxidative cyclization using elemental sulfur in the presence of a catalytic amount of iodine is inexpensive and worked well for a number of anilides. Copyright Taylor & Francis Group, LLC.

COMPOUND INHIBITING DIPEPTIDYL PEPTIDASE IV

The invention aims to provide a dipeptidyl peptidase IV inhibitor which is satisfactory in respect of activity, stability and safety and has an excellent action as a pharmaceutical agent. The invention is directed to a compound represented by the following general formula or a pharmaceutically acceptable salt thereof: wherein R1 and R2 each represents hydrogen, an optionally substituted C1-6 alkyl group, or -COOR5 whereupon R5 represents hydrogen or an optionally substituted C1-6 alkyl group, or R1 and R2, together with a carbon atom to which they are bound, represent a 3- to 6-membered cycloalkyl group, R3 represents hydrogen or an optionally substituted C6-10 aryl group, R4 represents a hydrogen or a cyano group, D represents -CONR6-, -CO- or -NR6CO-, R6 represents hydrogen or an optionally substituted C1-6 alkyl group, E represents -(CH2)m- whereupon m is an integer of 1 to 3, -CH2OCH2-, or -SCH2-, n is an integer of 0 to 3, and A represents an optionally substituted bicyclic heterocyclic group or bicyclic hydrocarbon group.

ADSORPTION AND LUMINESCENCE IN THE SERIES OF 2-PHENYLBENZOTHIAZOLE AND RELATED COMPOUNDS

Electronic transitions in the molecules of derivatives of 2-phenylbenzothiazole containing substituents in the annelated and 2-phenyl nuclei proceed with the participation of different excited states with charge transfer, their contribution depending on t