199929-31-2

Basic information

• Product Name: 3-hydroxy-N-p-tolylpropanamide
• Synonyms: 3-hydroxy-N-p-tolylpropanamide;3-Hydroxy-N-(4-methylphenyl)propanamide;p-Hydracrylotoluidide
• CAS NO: 199929-31-2
• Molecular Formula: C10H13NO2
• Molecular Weight: 179
• Mol File: 199929-31-2.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Density: 1.172
• CAS DataBase Reference: 3-hydroxy-N-p-tolylpropanamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-hydroxy-N-p-tolylpropanamide(199929-31-2)
• EPA Substance Registry System: 3-hydroxy-N-p-tolylpropanamide(199929-31-2)

Safety Data

• Hazardous Substances Data: 199929-31-2(Hazardous Substances Data)

Usage

General Description

3-hydroxy-N-p-tolylpropanamide, also known as tolperisone, is a chemical compound used as a muscle relaxant and pain reliever. It acts by blocking voltage-gated sodium channels in the central nervous system, leading to reduced nerve impulse conduction and muscle relaxation. It is often prescribed for the treatment of musculoskeletal and neurological conditions, such as muscle spasms, spasticity, and chronic pain. 3-hydroxy-N-p-tolylpropanamide has been found to be well-tolerated and effective in managing these conditions, with minimal sedative and cognitive side effects compared to other muscle relaxants. Additionally, it has shown promise in combination therapy for the treatment of various neuropathic pain syndromes. Overall, 3-hydroxy-N-p-tolylpropanamide is a valuable pharmaceutical agent with potential therapeutic applications in managing muscle and nerve-related disorders.

Upstream product

• 57-57-8 β-Propiolactone 
• 106-49-0 p-toluidine 
• 503-66-2 3-hydroxypropionic acid 
• 637-27-4 phenyl propionate 
• 38491-60-0 β-phenyl hydroxypropionate 
• 15258-46-5 N-allyl-p-toluidine 

Relevant articles and documents

CATALYST FOR CONVERTING ESTER TO AMIDE USING HYDROXYL GROUP AS ORIENTATION GROUP

Provided is a method for amidating a hydroxy ester compound at a high chemical selectivity. The amidation reaction method for a hydroxy ester compound comprises, in the presence of a catalyst containing a compound of a transition metal of the group 4 or group 5 in the periodic table, reacting at least one kind of hydroxy ester compound selected from the group consisting of an α-hydroxy ester compound, a β-hydroxy ester compound, a γ-hydroxy ester compound and a δ-hydroxy ester compound with an amino compound so as to amidate an ester group having a hydroxyl group at the α-, β-, γ- or δ-position of the hydroxy ester compound.

An Unexpected Construction of 2-Arylquinolines from N-Cinnamylanilines through sp3 Ci-H Aerobic Oxidation Induced by a Catalytic Radical Cation Salt

An unexpected reaction of cinnamylanilines was achieved through the radical cation salt-induced aerobic oxidation of sp3 C-H bonds, providing a series of 2-arylquinolines. The mechanistic study shows that the cinnamylaniline was oxidized to an imine, which was attacked by the aniline generated through decomposition of the corresponding imine. After further intramolecular cyclization and aromatization, 2-arylquinolines were obtained. This reaction provides a new method to construct 2-arylquinolines from readily accessible starting materials.