20001-64-3

Usage

Uses

Used in Pesticide Production:
1-CHLORO-2-(1-CHLOROETHYL)BENZENE is used as a key intermediate in the manufacturing process of certain pesticides. Its chemical properties allow for the creation of effective compounds designed to control, repel, or kill pests that can be harmful to agriculture and the environment.
Used in Pharmaceutical Industry:
In the pharmaceutical sector, 1-CHLORO-2-(1-CHLOROETHYL)BENZENE serves as an essential building block for the synthesis of specific drugs. Its unique structure contributes to the development of medicinal compounds with targeted therapeutic effects, addressing various health conditions and diseases.
Safety Considerations:
Given its hazardous nature, 1-CHLORO-2-(1-CHLOROETHYL)BENZENE poses risks if inhaled, ingested, or upon contact with the skin or eyes. It can lead to irritation, respiratory issues, and central nervous system effects. Therefore, it is imperative to handle this chemical with extreme caution and adhere to stringent safety protocols to minimize potential health and environmental impacts.

InChI:InChI=1/C8H8Cl2/c1-6(9)7-4-2-3-5-8(7)10/h2-6H,1H3

Upstream product

• 13524-04-4 2'-chloro-sec-phenethyl alcohol 
• 89-96-3 1-chloro-2-ethylbenzene 
• 2142-68-9 1-(2-chlorophenyl)ethanone 

Downstream Products

• 66897-87-8 N-Allyl-N-[1-(2-chloro-phenyl)-ethyl]-benzenesulfonamide 

Relevant academic research and scientific papers

Ferric chloride–catalyzed deoxygenative chlorination of carbonyl compounds: A comparison of chlorodimethylsilane and dichloromethylsilane system

Deoxygenative chlorination of carbonyl compounds using the HMe2SiCl/FeCl3/EtOAc and HMeSiCl2/FeCl3/EtOAc systems has been systemically investigated. The HMe2SiCl-FeCl3 system showed the advantages of good substrate applicability, mild reaction conditions, simple operation, low cost, and easy availability of raw materials. Also, it provided a simple and efficient synthesis route for carbonyl deoxychlorination via a one-pot method. Using the HMeSiCl2/FeCl3/EtOAc system, the β-methylchalcone derivative could be obtained in good yields in addition to obtaining the chlorinated compound. Finally, two plausible reaction routes were proposed to describe the formation of the chlorinated compound and the β-methylchalcone derivative.

Iron-catalysed enantioconvergent Suzuki-Miyaura cross-coupling to afford enantioenriched 1,1-diarylalkanes

The first stereoconvergent Suzuki-Miyaura cross-coupling reaction was developed to afford enantioenriched 1,1-diarylalkanes. An iron-based complex containing a chiral cyanobis(oxazoline) ligand framework was best to obtain enantioenriched 1,1-diarylalkanes from cross-coupling reactions between unactivated aryl boronic esters and benzylic chlorides. Enhanced yields were obtained when 1,3,5-trimethoxybenzene was used as an additive, which is hypothesized to extend the lifetime of the iron-based catalyst. Exceptional enantioselectivities were obtained with challenging ortho-substituted benzylic chlorides. This journal is

Ketone-catalyzed photochemical C(sp3)–H chlorination

Photoexcited arylketones catalyze the direct chlorination of C(sp3)–H groups by N- chlorosuccinimide. Acetophenone is the most effective catalyst for functionalization of unactivated C–H groups while benzophenone provides better yields for benzylic C–H functionalization. Activation of both acetophenone and benzophenone can be achieved by irradiation with a household compact fluorescent lamp. This light-dependent reaction provides a better control of the reaction as compared to the traditional chlorination methods that proceed through a free radical chain propagation mechanism.

Iron catalyzed halogenation of benzylic aldehydes and ketones

A simple and efficient iron-catalyzed method for chlorination of aromatic carbonyl compounds is reported. By using 4-10 mol% Fe(iii) oxo acetate catalyst, prepared by solid state atmospheric oxidation of Fe(ii) acetate, in combination with triethylsilane and chlorotrimethylsilane, hydrosilylation of benzylic carbonyl compounds with subsequent chlorination is achieved within a few hours at room temperature. This new method is mild and rapid compared to the conventional two step approach involving reduction and chlorination reactions in separate stages. Development of synthetic methodology is also supplemented here by kinetic investigation of the reaction mechanism, which supports the tentative mechanisms suggested previously for similar reactions. This journal is

NOVEL 5-SUBSTITUTED 7-AMINO-[1,3]THIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES

There are disclosed novel 5-substituted 7-amino-[1,3]thiazolo[4,5-d]pyrimidine derivatives of formula (I) wherein R1, R2, R3, R4 and R5 are as defined in the specification, and pharmaceutically accept