1-CHLORO-2-(1-CHLOROETHYL)BENZENE

Base Information

• Chemical Name: 1-CHLORO-2-(1-CHLOROETHYL)BENZENE
• CAS No.: 20001-64-3
• Molecular Formula: C8H8Cl2
• Molecular Weight: 175.058
• Hs Code.: 2903999090
• Mol file: 20001-64-3.mol

Synonyms:Benzene, 1-chloro-2-(1-chloroethyl)-;1-Chlor-1-<2-chlor-phenyl>-aethan;

Chemical Property of 1-CHLORO-2-(1-CHLOROETHYL)BENZENE

Chemical Property:

• Vapor Pressure: 0.216mmHg at 25°C
• Boiling Point: 215.5oC at 760 mmHg
• Flash Point: 80.8oC
• PSA: 0.00000
• Density: 1.196g/cm3
• LogP: 3.63980

Purity/Quality:

98.5% ^*data from raw suppliers

1-Chloro-2-(1-chloroethyl)benzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-CHLORO-2-(1-CHLOROETHYL)BENZENE

There total 4 articles about 1-CHLORO-2-(1-CHLOROETHYL)BENZENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1-(2-chlorophenyl)ethanone (2142-68-9) → 1-chloro-2-(1-chloroethyl)benzene (20001-64-3)

Guidance literature:

With chloro-trimethyl-silane; trimethylsilan; In acetic acid methyl ester; at 20 ℃; for 2h;

DOI:10.1039/c5cy00067j

Reference yield: 79.0%

2'-chloro-sec-phenethyl alcohol (13524-04-4) → 1-chloro-2-(1-chloroethyl)benzene (20001-64-3)

Guidance literature:

With thionyl chloride; sodium hydrogencarbonate; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1039/d0cc05003b

Reference yield: 64.0%

1-chloro-2-ethylbenzene (89-96-3) → 1-chloro-2-(1-chloroethyl)benzene (20001-64-3) + 2-chlorophenylethyl chloride (1005-06-7)

Guidance literature:

With N-chloro-succinimide; benzophenone; In acetonitrile; at 27 ℃; for 24h; regioselective reaction; Irradiation;

DOI:10.1016/j.tet.2017.05.008

upstream raw materials:

2'-chloro-sec-phenethyl alcohol

1-(2-chlorophenyl)ethanone

1-chloro-2-ethylbenzene

Downstream raw materials:

N-Allyl-N-[1-(2-chloro-phenyl)-ethyl]-benzenesulfonamide

Refernces

• 1、 Xing, Bing-Han,Zhao, Xuan-Xuan,Qin, Yu-Jun,Zhang, Pu,Guo, Zhi-Xin. "Ferric chloride–catalyzed deoxygenative chlorination of carbonyl compounds: A comparison of chlorodimethylsilane and dichloromethylsilane system". . p. 667 - 675. Retrieved 2020/05/22.
• 2、 Savela, Risto,W?rn?, Johan,Murzin, Dmitry Yu.,Leino, Reko. "Iron catalyzed halogenation of benzylic aldehydes and ketones". . p. 2406 - 2417. Retrieved 2015/04/14.