20005-55-4

Upstream product

• 22731-70-0 1-(4-bromophenyl)prop-2-en-1-one 
• 76346-17-3 3-(4-bromophenyl)but-2-enoic acid ethyl ester 
• 99-90-1 para-bromoacetophenone 
• 96090-12-9 p-bromo-cinnamyl bromide 
• 917-54-4 methyllithium 
• 1021735-42-1 methyl 3-(4-bromophenyl)butanoate 
• 159755-11-0 1-bromo-4-(1-bromoethyl)benzene 

Downstream Products

• 86456-65-7 Methanesulfonic acid 3-(4-bromo-phenyl)-butyl ester 
• 31042-07-6 4-(4-bromophenyl)pentanoic acid 
• 86456-68-0 6-bromo-1-methylnaphthalene 
• 86456-56-6 6-bromo-1-naphthaldehyde 
• 86456-66-8 4-(4-bromophenyl)pentanenitrile 
• 86456-62-4 o-<(6-bromo-1-naphthyl)methyl>acetophenone 
• 86456-60-2 o-<(6-bromo-1-naphthyl)methyl>benzoic acid 
• 86456-72-6 2-(6-Bromo-naphthalen-1-ylmethyl)-benzoyl chloride 
• 1021735-47-6 3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]butanol 

Relevant academic research and scientific papers

Alkyl Ethers as Traceless Hydride Donors in Br?nsted Acid Catalyzed Intramolecular Hydrogen Atom Transfer

A new protocol for the deoxygenation of alcohols and the hydrogenation of alkenes under Br?nsted acid catalysis has been developed. The method is based on the use of either a benzyl or isopropyl ether as a traceless hydrogen-atom donor, and involves an intramolecular hydride transfer as a key step, which is achieved in a regio- and stereoselective manner.

BIARYL DERIVATIVE AS GPR120 AGONIST

The present invention relates to a biaryl derivative expressed by the chemical formula 1, a method for producing the biaryl derivative, a pharmaceutical composition comprising same, and use of same, the biaryl derivative expressed by the chemical formula 1, as a GPR120 agonist, promoting GLP-1 generation in the gastro-intestinal tract, reducing insulin resistance in the liver, muscles and the like from anti-inflammatory activity in the macrophage, pancreatic cells and the like, and allowing effective use in prevention or treatment of inflammation or metabolic diseases such as diabetes, complications from diabetes, obesity, non-alcoholic fatty liver disease, fatty liver disease, and osteoporosis.

Synthesis of optically active β- Or γ-alkyl-substituted alcohols through copper-catalyzed asymmetric allylic alkylation with organolithium reagents

An efficient one-pot synthesis of optically active β-alkyl-substituted alcohols through a tandem copper-catalyzed asymmetric allylic alkylation (AAA) with organolithium reagents and reductive ozonolysis is presented. Furthermore, hydroboration-oxidation following the Cu-catalyzed AAA leads to the corresponding homochiral γ-alkyl-substituted alcohols.

SUBSTITUTED IMIDAZOLES AS BOMBESIN RECEPTOR SUBTYPE-3 MODULATORS

Certain novel substituted imidazoles are ligands of the human bombesin receptor and, in particular, are selective ligands of the human bombesin receptor subtype-3 (BRS-3). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the modulation of BRS-3, such as obesity, and diabetes.