200132-62-3

Upstream product

• 27532-96-3 glycine tert-butyl ester hydrochloride 
• 1013-88-3 Benzophenone imine 
• 1458-98-6 2-methyl-3-bromo-1-propene 
• 81477-94-3 N-(diphenylmethylene)glycine tert-butyl ester 

Downstream Products

• 171881-79-1 (S)-2-(benzyloxycarbonylamino)-4-methylpent-4-enoic acid 
• 87325-47-1 (2S)-2-tert-butoxycarbonylamino-4-methyl-4-pentenoic acid 
• 87392-13-0 (2S)-2-amino-4-methylpent-4-enoic acid 

Relevant academic research and scientific papers

Total synthesis of (+)-hygrine via asymmetric phase-transfer catalytic alkylation

The first enantioselective synthesis of (+)-hygrine (1) is reported. 1 was obtained in 12 steps with 29% overall yield and 97% ee via asymmetric phase-transfer catalytic alkylation and ring-closing metathesis as key steps. The absolute configuration of (+

Expedient Synthesis of Fmoc-(S)-γ-Fluoroleucine and Late-Stage Fluorination of Peptides

A concise synthesis of (S)-γ-fluoroleucine is described in five steps from commercially available compounds, with an overall yield of 57%. The Markovnikov hydrofluorination reaction of the unsaturated amino acid precursor as last step of the synthesis pro

Asymmetric alkylation of glycine imines using in situ generated phase-transfer catalysts

In this paper we report an investigation into the possibility of effecting the asymmetric alkylation of glycine imines using chiral quaternary ammonium salt catalysts that are generated in situ. It is demonstrated that O-alkyl N-alkyldihydrocinchonidinium salts can be assembled from the parent alkaloid under the reaction conditions required for the liquid-liquid phase-transfer alkylation of glycine imines, and that reactions performed in this way give enantioselectivities comparable to those obtained using pre-prepared catalysts. Utilization of this methodolgy in the generation and screening of catalyst libraries is also demonstrated.

Total Synthesis of Alloviroidin

Alloviroidin is a cyclic heptapeptide, produced by several species of Amanita mushrooms, that demonstrates high affinity for F-actin as is characteristic of virotoxins and phallotoxins. Alloviroidin was synthesized via a [3 + 4] fragment condensation of F

Dimeric cinchona ammonium salts with benzophenone linkers: Enantioselective phase transfer catalysts for the synthesis of α-Amino acids

Chiral phase transfer catalysts of dimeric cinchona ammonium salts linked with a benzophenone bridge showed high enantioselectivity in the α-Alkylation of a glycinate ester under mild industry-Applicable conditions: 0.5 mol% PTC and near equivalents of al

ANTHELMINTIC DEPSIPEPTIDE COMPOUNDS

The present invention provides cyclic depsipeptide compounds of formula (I) wherein the stereochemical configuration of at least one carbon atom bearing the groups Cy1, Cy2, R1, R2, R3, R4, Ra and Rb is inverted compared with the naturally occurring cyclic depsipeptide PF1022A. The invention also provides compositions comprising the compounds that are effective against parasites that harm animals. The compounds and compositions may be used for combating parasites in or on mammals and birds. The invention also provides for an improved method for eradicating, controlling and preventing parasite infestation in birds and mammals.

Heterogeneous simplified Maruoka phase-transfer catalyst tethered on poly(styrene-co-acrylamide) microsphere: Structure-activity relationship in enantioselective Α-alkylation

The covalent immobilization of valuable simplified Maruoka catalyst onto poly(styrene-co-acrylamide)microsphere at different locations was developed for the first time through the copolymerization of Maruoka catalyst-functionalized styrene with styrene an

ANTHELMINTIC DEPSIPEPTIDE COMPOUNDS

The present invention provides cyclic depsipeptide compounds of formula (I) and compositions comprising the compounds that are effective against parasites that harm animals. The compounds and compositions may be used for combating parasites in or on mammals and birds. The invention also provides for an improved method for eradicating, controlling and preventing parasite infestation in birds and mammals.

Facile one-pot fabrication of a silica gel-supported chiral phase-transfer catalyst - N-(2-cyanobenzyl)-O(9)-allyl-cinchonidinium salt

A novel type of silica gel-supported cinchona alkaloid-based quaternary ammonium salt was prepared by available one-pot synthesis for the first time through the free radical addition of the sulfhydryl group of 3-mercaptopropyltrimethoxysilane to an exocyc

9-Amino-(9-deoxy)cinchona alkaloid-derived new chiral phase-transfer catalysts

A new class of 9-amino-(9-deoxy)cinchona alkaloid-derived chiral phase-transfer catalysts bearing amino groups was developed by using known cinchona alkaloids as the starting materials. Due to the transformation of the 9-hydroxyl group into a 9-amino functional group, the catalytic performances were significantly improved in comparison with the corresponding first generation phase-transfer catalysts, and excellent yields (92-99%) and high enantioselectivities (87-96% ee) were achieved in the benchmark asymmetric α-alkylation of glycine Schiff base. Based on the special contribution of the amino group to the high yield and enantioselectivity, the possible catalytic mechanism was conjectured. This journal is