200191-86-2

Usage

Uses

Used in Pharmaceutical Industry:
Z-D-ARG(Z)2-OSU is used as a protease inhibitor for its potential therapeutic applications in neurodegenerative disorders such as Alzheimer's disease. The inhibition of prolyl oligopeptidase by Z-D-ARG can help in managing the degradation of neuropeptides, which is implicated in the progression of these disorders.
Used in Drug Development:
Z-D-ARG(Z)2-OSU is utilized in the development of novel protease inhibitors that can target specific enzymes involved in neurodegenerative processes. Z-D-ARG(Z)2-OSU's unique structure, with the OSU masking group, contributes to improved stability and bioavailability, making it a promising candidate for further research and potential clinical applications.

Upstream product

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Relevant academic research and scientific papers

Direct PCR amplification of various modified DNAs having amino acids: Convenient preparation of DNA libraries with high-potential activities for in vitro selection

We synthesized modified 2′-deoxyuridine triphosphates bearing amino acids at the C5 position and investigated their substrate properties for KOD Dash DNA polymerase during polymerase chain reaction (PCR). PCR using C5-modified dUTP having an amino acyl group (arginyl, histidyl, lysyl, phenylalanyl, tryptophanyl, leucyl, prolyl, glutaminyl, seryl, O-benzyl seryl or threonyl group) gave the corresponding full-length PCR products in good yield. Although dUTP analogues bearing aspartyl, glutamyl or cysteinyl were found to be poor substrates for PCR catalyzed by KOD Dash DNA polymerase, optimization of the reaction conditions resulted in substantial generation of full-length product. In the case of reaction using dUTP analogue having a cysteinyl group, addition of a reducing agent improved the reaction yield. Thus, PCRs using KOD Dash DNA polymerase together with amino acyl dUTP provide convenient and efficient preparation of various modified DNA libraries with potential protein-like activities.