200207-21-2Relevant articles and documents
PYRIDINYL AND PYRAZINYL-(AZA)INDOLSULFONAMIDES
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Page/Page column 86-87; 89, (2020/01/11)
The present invention relates to pyridinyl and pyrazinyl-(aza)indolsulfonamides having GPR17 modulator activity. The compounds have utility in the treatment of a variety of GPR17-associated disorders.
QUINUCLIDINES FOR MODULATING ALPHA 7 ACTIVITY
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Paragraph 0350, (2016/02/29)
Provided are substituted quinuclidine compounds, pharmaceutical compositions comprising such compounds, and methods of modulating α7 nicotinic acetylcholine receptors and treating neurological disorders using such compounds.
Discovery of N-(4′-(indol-2-yl)phenyl)sulfonamides as novel inhibitors of HCV replication
Chen, Guangming,Ren, Hongyu,Turpoff, Anthony,Arefolov, Alexander,Wilde, Richard,Takasugi, James,Khan, Atiyya,Almstead, Neil,Gu, Zhengxian,Komatsu, Takashi,Freund, Connie,Breslin, Jamie,Colacino, Joseph,Hedrick, Jean,Weetall, Marla,Karp, Gary M.
, p. 3942 - 3946 (2013/07/27)
A series of novel 2-phenylindole analogs were synthesized and evaluated for activity in subgenomic HCV replicon inhibition assays. Several compounds containing small alkyl sulfonamides on the phenyl ring exhibiting submicromolar EC50 values against the genotype 1b replicon were identified. Among these, compound 25d potently inhibited the 1b replicon (EC50 = 0.17 μM) with 147-fold selectivity with respect to cytotoxicity. Compound 25d was stable in the presence of human liver microsomes and had a good pharmacokinetic profile in rats with an IV half-life of 4.3 h and oral bioavailability (F) of 58%.