898746-82-2

Basic information

• Product Name: N-BOC-6-METHOXYINDOLE
• Synonyms: TERT-BUTYL 6-HYDROXY-1H-INDOLE-1-CARBOXYLATE;1H-Indole-1-carboxylicacid,6-hydroxy-,1,1-diMethylethylester
• CAS NO: 898746-82-2
• Molecular Formula: C₁₃H₁₅NO₃
• Molecular Weight: 233.26
• Mol File: 898746-82-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 374.5±34.0 °C(Predicted)
• Appearance: /
• Density: 1.16±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 9.48±0.40(Predicted)
• CAS DataBase Reference: N-BOC-6-METHOXYINDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: N-BOC-6-METHOXYINDOLE(898746-82-2)
• EPA Substance Registry System: N-BOC-6-METHOXYINDOLE(898746-82-2)

Safety Data

• Hazardous Substances Data: 898746-82-2(Hazardous Substances Data)

Usage

Synthesis

Tert-butyl 6-fluoro-5-hydroxy-1H-indazole-1-carboxylate was prepared as described for intermediate tert-butyl 5-hydroxy-1H-indazole-1-carboxylate/ tert-butyl 5-hydroxy-2H-indazole-2- carboxylate replacing tert-butyl 5-((tert-butyldimethylsilyl)oxy)-1H-indazole-1-carboxylate / tert-butyl 5-((tertbutyldimethylsilyl) oxy)-2H-indazole-2-carboxylate with tert-butyl 5-((tert-butyldimethylsilyl)oxy)-6-fluoro-1H-indazole-1-carboxylate(yield: 94%). 1H NMR (400 MHz, Chloroform-d) δ 8.06 (d, J = 0.9 Hz, 1H), 7.95 (d, J = 10.7 Hz, 1H), 7.28 (d, J = 8.2 Hz, 2H), 5.48 (s, 1H), 1.71 (s, 9H).

Upstream product

• 2380-86-1 6-hydroxy-1H-indole 
• 24424-99-5 di-tert-butyl dicarbonate 
• 15903-94-3 6-benzyloxy-1H-indole 
• 933474-39-6 6-benzyloxy-indole-1-carboxylic acid tert-butyl ester 

Downstream Products

• 200207-21-2 6-(difluoromethoxy)-1H-indole 

Relevant articles and documents

Rapid access to spirocyclic oxindole alkaloids: Application of the asymmetric palladium-catalyzed [3 + 2] trimethylenemethane cycloaddition

The marcfortines are complex secondary metabolites that show potent anthelmintic activity and are characterized by the presence of a bicyclo[2.2.2]diazaoctane fused to a spirooxindole. Herein, we report the synthesis of two members of this family. The syn

PYRIDINYL AND PYRAZINYL-(AZA)INDOLSULFONAMIDES

The present invention relates to pyridinyl and pyrazinyl-(aza)indolsulfonamides having GPR17 modulator activity. The compounds have utility in the treatment of a variety of GPR17-associated disorders.

Concise, asymmetric, stereocontrolled total synthesis of stephacidins A, B and notoamide B

Concise asymmetric total syntheses of the fungal metabolites (-)-stephacidin A, (+)-stephacidin B, and (+)-notoamide B are described. Key features of these total syntheses include (1) a facile synthesis of (R)-allyl proline methyl ester, (2) a revised rou