200286-04-0Relevant articles and documents
Syntheses, Structures, and Magnetic Properties of Symmetric and Dissymmetric Ester-Functionalized 3d-4f Schiff Base Complexes
Béreau, Virginie,Dhers, Sébastien,Costes, Jean-Pierre,Duhayon, Carine,Sutter, Jean-Pascal
, p. 66 - 73 (2018)
Ester-functionalized bicompartmental Schiff base ligands and their 3d-Ln complexes (3d = NiII, CuII, or ZnII and Ln = GdIII, TbIII, or DyIII) are reported. The modularity of the Schiff base structure (i.e., symmetric ester group compared with dissymmetric ester group) is illustrated to highlight the possibility offered by the ester for facile functionalization at the periphery of the ligand, in addition to its electron-withdrawing effect on the complexing core. The introduction of a chiral pool (i.e., a menthyl group) at the ester functions led to a transfer of chirality to the coordination sphere of the Ln in the solid state. Several 3d-4f complexes were found to crystallize as (NO3–)- or (OH–)-bridged compounds. Crystal structures and magnetic behaviors are reported for all of the 3d-4f complexes.
Bi-Compartmental Schiff-Base with Peripheral Ester Functionalization: Synthesis and Magnetic Behavior of Bimetallic Zn-Ln Complexes (Ln = Dy, Tb, Gd)
Béreau, Virginie,Bolvin, Hélène,Duhayon, Carine,Sutter, Jean-Pascal
, p. 4988 - 4995 (2016)
A novel ester-functionalized bi-compartmental Schiff-base ligand and its dinuclear Zn-Ln complexes [Ln = Dy (1), Tb (2), Gd (3)] are reported herein. Athough electron-withdrawing substituents at the para position of the phenol moieties do not change the coordination environment of the Ln centers in comparison with the nonfunctionalized ligand, they have a clear steric effect on the crystal packing and alter the coordination strength of the central ligand core. This is illustrated by the atypical reactivity of the bi-compartmental Schiff-base ligand towards Ln coordination and corroborated by its longer bond lengths to the rare-earth ions in comparison with the nonfunctionalized ligand. Crystal structures, magnetic behavior, and ab initio calculations for the two series of complexes are reported. A slow relaxation of the magnetization with an energy barrier of 96 K was found for Dy derivative 1 in zero field.
PYRROLIDINE DERIVATIVE
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Paragraph 0198, (2019/04/16)
The present invention aims to provide a novel compound which has CGRP receptor antagonist activity and which is useful for the treatment of various diseases mediated by CGRP receptors. That is, the present invention relates to the pyrrolidine derivatives represented by the following formula (I) or a pharmaceutically acceptable salt thereof. In the formulae, W is ring, X is a carbon atom or the like, Y1 to Y4 are carbon atoms or the like, and R1 to R7 is alkyl or the like. The compounds of the present invention or a pharmaceutically acceptable salt thereof have an excellent CGRP receptor antagonist activity, and thus are useful as agents for the treatment of various diseases mediated by CGRP receptors.
Ring-expansion of 2-methylbenzo[b]furan to 3-hydroxychromen-4-one: A potential approach to a flavonol skeleton
Ishikawa, Tsutomu,Miwa, Chizue
, p. 2273 - 2276 (2007/10/03)
A 2-methylbenzo[b]furan, prepared by the CsF-mediated Claisen rearrangement of a phenyl propargyl ether, could be smoothly transformed into a 3-hydroxychromen-4-one, a potential flavonol skeleton, by three successive treatment with NBS, OsO4, and Na2SO3.
