200293-66-9Relevant academic research and scientific papers
PHENYLSULFONAMIDE DERIVATIVES
-
, (2008/06/13)
A phenylsulfonamide derivative of formula (I) (wherein R1 is H, alkyl; R2 is COOR3, CONHOR4; E is vinylene, ethynylene; A is H, alkyl, a carbocyclic ring, a heterocyclic ring; J is a single bond, aklylene; R9, R10 is H, (substituted) alkyl, COR11, a carbo
Highly selective and orally active inhibitors of type IV collagenase (MMP-9 and MMP-2): N-sulfonylamino acid derivatives
Tamura, Yoshinori,Watanabe, Fumihiko,Nakatani, Takuji,Yasui, Ken,Fuji, Masahiro,Komurasaki, Tadafumi,Tsuzuki, Hiroshige,Maekawa, Ryuji,Yoshioka, Takayuki,Kawada, Kenji,Sugita, Kenji,Ohtani, Mitsuaki
, p. 640 - 649 (2007/10/03)
Various N-sulfonylamino acid derivatives were synthesized and evaluated for their in vitro and in vivo activities to inhibit type IV collagenase (MMP-9 and MMP-2). When the amino acid residue and the sulfonamide moiety were modified, their inhibitory activities were greatly affected by the structure of the sulfonamide moiety. A series of aryl sulfonamide derivatives containing biaryl, tetrazole, amide, and triple bond were found to be potent and highly selective inhibitors of MMP-9 and MMP-2. In addition, these compounds were orally active in animal models of tumor growth and metastasis. These results revealed the potential of the N-sulfonylamino acid derivatives as a new type of candidate drug for the treatment of cancer.
