37735-10-7

Usage

Explanation

The molecular formula represents the number of atoms of each element present in a molecule. In this case, the compound has 10 carbon (C) atoms, 9 hydrogen (H) atoms, 3 nitrogen (N) atoms, and 1 oxygen (O) atom.

Explanation

The compound's structure consists of two fused rings, one being a benzene ring and the other an imidazole ring. This arrangement gives the compound its aromatic properties.

Explanation

The aldehyde functional group (-CHO) is present in the molecule and is attached to the 2nd carbon atom of the imidazole ring.

Explanation

The compound has two methyl groups (-CH3) attached to the benzene ring, one at the 1st position and the other at the 5th position.

Explanation

1H-Benzimidazole-2-carboxaldehyde,1,5-dimethyl-(9CI) is derived from benzimidazole, which is a bicyclic aromatic compound consisting of a benzene ring fused to an imidazole ring.

Explanation

Due to its unique structure and chemical properties, the compound may be used as a building block or intermediate in the synthesis of various organic compounds, pharmaceuticals, and materials.

Explanation

The compound's structure and functional groups make it a versatile building block that can be used to create a wide range of organic compounds and materials for various applications.

Structure

Bicyclic aromatic compound with a benzene ring fused to an imidazole ring

Aldehyde functional group

Located at the 2-position

Methyl groups

Two methyl groups at the 1and 5-positions

Derivative of benzimidazole

A bicyclic aromatic compound

Potential applications

Organic synthesis, pharmaceuticals, and materials science

Versatile building block

Synthesis of various organic compounds and materials

Upstream product

• 20034-02-0 (5-methyl-1H-benzimidazole-2-yl)methanol 
• 74-88-4 methyl iodide 
• 496-72-0 4-methyl-1,2-diaminobenzene 
• 68426-72-2 (N-methyl-5-methyl-1H-benzimidazole-2-yl)methanol 

Downstream Products

• 1357162-35-6 C₂₁H₂₀N₂O₃ 

Relevant academic research and scientific papers

New (E)-1-alkyl-1H-benzo[d]imidazol-2-yl)methylene)indolin-2-ones: Synthesis, in vitro cytotoxicity evaluation and apoptosis inducing studies

A new series of (E)-benzo[d]imidazol-2-yl)methylene)indolin-2-one derivatives has been synthesized and evaluated for their in vitro cytotoxic activity against a panel of selected human cancer cell lines of prostate (PC-3 and DU-145) and breast (BT-549, MDA-MB-231, MCF-7, 4T1), non-small lung (A549) and gastric (HGC) cancer cells along with normal breast epithelial cells (MCF10A). Among the tested compounds, 8l showed significant cytotoxic activity against MDA-MB-231 and 4T1 cancer cells with IC50values of 3.26 ± 0.24 μM and 5.96 ± 0.67 μM respectively. The compounds 8f, 8i, 8l and 8o were also screened on normal human breast epithelial cells (MCF10A) and found to be safer with lesser cytotoxicity. The treatment of MDA-MB-231 cells with 8l led to inhibition of cell migration ability through disruption of F-actin protein assembly. The flow-cytometry analysis reveals that the cells arrested in G0/G1 phase of the cell cycle. Further, the compound 8l induced apoptosis of MDA-MB-231 cells was characterized by different staining techniques such as Acridine Orange/Ethidium Bromide (AO/EB), DAPI, annexin V-FITC/PI, Rhodamine-123 and MitoSOX red assay. Western blot studies demonstrated that the compound 8l treatment led to activation of caspase-3, increased expression of cleaved PARP, increased expression of pro-apoptotic Bax and decreased expression of anti-apoptotic Bcl-2 in MDA-MB-231 cancer cells.

Synthesis of substituted benzimidazolyl curcumin mimics and their anticancer activity

A novel curcumin mimic library (14a-14h and 15a-15h) possessing variously substituted benzimidazole groups was synthesized through the aldol reaction of (E)-4-(4-hydroxy-3-methoxyphenyl)but-3-en-2-one (7) or (E)-4-(3-hydroxy-4- methoxyphenyl)but-3-en-2-one (13) with diversely substituted benzimidazolyl-2-carbaldehyde (12a-12h). The MTT assay of the cancer cells MCF-7, SH-SY5Y, HEP-G2, and H460 showed that compound 14c with IC50 of 1.0 and 1.9 μM has a strong inhibitory effect on the growth of SH-SY5Y and Hep-G2 cells, respectively, and that compound 15h with IC50 of 1.9 μM has a strong inhibitory effect on the growth of MCF-7 cancer cells.

6-(SUBSTITUTED)METHYLENE-PENICILLANIC AND 6-(SUBSTITUTED)HYDROXYMETHYL-PENICILLANIC ACIDS AND DERIVATIVES THEREOF

Beta-lactamase inhibiting compounds of the formula: or a pharmaceutically acceptable acid addition or carboxylate salt thereof; where n is zero, 1 or 2; X.3 is H or Br, R1 is H, the residue of certain carboxy-protecting groups or the residue of an ester group readily hydrolyzable in vivo; one of R12 and R13 is H and the other is vinyl, certain aryl, alkylthio, alkylsulfonyl or certain heterocyclyl, aminomethyl, thiocarboxamido or amidino groups; one or R2 and R3 is H and the other is as disclosed for the other of R12 and R13, or is Cl or CH2 OH, and R18 is H or certain acyl groups; intermediates useful in their production, methods for their preparation and use, and pharmaceutical compositions containing them