20036-97-9Relevant academic research and scientific papers
Identification and optimization of small molecule antagonists of vasoactive intestinal peptide receptor-1 (VIPR1)
Harikrishnan, Lalgudi S.,Srivastava, Neelam,Kayser, Lauren E.,Nirschl, David S.,K, Kumaragurubaran,Roy, Amrita,Gupta, Anuradha,Karmakar, Sukhen,Karatt, Tajudheen,Mathur, Arvind,Burford, Neil T.,Chen, Jing,Kong, Yan,Cvijic, Maryellen,Cooper, Christopher B.,Poss, Michael A.,Trainor, George L.,Wong, Tai W.
scheme or table, p. 2287 - 2290 (2012/04/18)
Identification, synthesis and structure-activity relationship of small-molecule VIPR1 antagonists encompassing two chemical series are described.
Reactions of 2-amino-4,5,6,7-tetrahydro[1]benzothiophene-3-carbonitrile and 6-amino-1,4-dihydro-3-methyl-1,4-diphenylpyrano[2,3-c]pyrazole-5-carbonitrile with substituted benzylidenemalononitriles, α,β-acetylenic esters and ketones
Said, Ahmed,Youssef, Ahmed
experimental part, p. 214 - 217 (2009/12/03)
Reactions of 2-amino-4,5,6,7-tetrahydro[1]benzothiophene-3-carbonitrile (1a) with substituted benzylidenemalononitriles gave 4-amino-2-(1-cyano-2- arylvinyl)benzothieno[2,3-d]pyrimidine derivatives (3) as (E,Z)-mixtures and in one case (2c) as separated (
Synthesis, Antitumor and Anti-HIV-1 Testing of Certain Thieno[2,3-d]pyrimidine, Thieno[2,3-d]imidazo[1,2-c] pyrimidine and Thieno[2,3-d][1,3]thiazine Derivatives
Shehata,El-Subbagh,Abdelal,El-Sherbeny,Al-Obaid
, p. 148 - 163 (2007/10/03)
A series of tetrahydrobenzo[b]thieno[2,3-d]pyrimidines, thieno[3,2-e]imidazo[1,2-c]pyrimidines and thieno[2,3-dt][1,3]thiazines was synthesized as antitumor, antiviral agents. Compounds 2, 3 and 17 possessed moderate Anti-HIV-1 potency with EC50 values ranging from 1.83 × 10-5 to 3.42 × 10-5 molar concentrations. All of the tested compounds showed cytotoxic effects (log GI50 ≤ -4.0) against the growth of a variety of human tumor cell lines, including those derived from solid tumors. Compounds 3 and 7 showed strong potency while compounds 11 and 16 exhibited moderate activity. The detailed synthesis, spectroscopic and biological data are reported.
Derivatives of thiophene
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, (2008/06/13)
New dicyclic thiophene compounds having the structural formula STR1 wherein X is an ester or cyano group and Y is a substituted amino group. The compounds are useful as agricultural chemicals and particularly as ripeners for sugarcane.
Use of polycyclic thiophene compounds as ripeners for sugarcane
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, (2008/06/13)
Sucrose yield of sugarcane is increased by treating the cane crop a few weeks prior to harvest with a certain type of polycyclic thiophene compound of the formula SPC1 Wherein X is cyano, carboalkoxy or carbamido and Y is an amino or substituted amino group, or with mixtures comprising one or more such compounds.
