200405-51-2Relevant academic research and scientific papers
First total synthesis of the bone resorption markers deoxypyridinoline and hydroxypyridinoline
Waelchli, Rudolf,Beerli,Meigel,Revesz
, p. 2831 - 2836 (1997)
The first total synthesis of the collagen crosslinks deoxypyridinoline 1 and hydroxypyridinoline 2 was achieved. The key intermediate, pyridine 3 served as starting material for the preparation of compounds 1 and 2 and derivatives of 1. These compounds create optimal tools to establish a diagnostic kit for bone resorption.
