First total synthesis of the bone resorption markers deoxypyridinoline and hydroxypyridinoline

Article abstract of DOI:10.1016/S0960-894X(97)10084-1

The first total synthesis of the collagen crosslinks deoxypyridinoline 1 and hydroxypyridinoline 2 was achieved. The key intermediate, pyridine 3 served as starting material for the preparation of compounds 1 and 2 and derivatives of 1. These compounds create optimal tools to establish a diagnostic kit for bone resorption.