200422-17-9Relevant academic research and scientific papers
4-[18F]fluorophenyl ureas via carbamate-4-nitrophenyl esters and 4-[18F]fluoroaniline
Olma, Sebastian,Ermert, Johannes,Coenen, Heinz H.
, p. 1037 - 1050 (2007/10/03)
Four different no carrier added (n.c.a.) 4-[18F]fluorophenylurea derivatives are synthesized as model compounds via two alternative routes. In both cases carbamate-4-nitrophenylesters are used as intermediates. Either n.c.a. 4-[18F]fluoroaniline reacts with carbamates of several amines, or the carbamate of n.c.a. 4-[18F]fluoroaniline is formed at first and an amine is added subsequently to yield the urea derivative. The choice of the appropriate way of reaction depends on the possibilities of precursor synthesis. The radiochemical yields reach up to 80% after 50 min of synthesis time while no radiochemical by-products can be determined. These high yields were possible due to an optimized preparation of n.c.a. 4-[18F] fluoroaniline with a radiochemical yield of up to 90%. From the various ways of its radiosynthesis, the substitution with n.c.a. [18F]fluoride on dinitrobenzene is chosen, using phosphorous acid and palladium black for reduction of the second nitro group. Copyright
ACETYLENIC ALPHA-AMINO ACID-BASED SULFONAMIDE HYDROXAMIC ACID TACE INHIBITORS
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Page 91, (2010/02/07)
Compound of the formula (B) are useful in treating disease conditions mediated by TNF- alpha , such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.
