20052-37-3

Upstream product

• 10493-03-5 3',4',5,7-tetramethoxyflavylium chloride 
• 490-46-0 (2R,3R)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-1[2H]-benzopyran-3,5,7-triol 
• 51196-02-2 5,7,3',4'-tetra-O-methylepicatechin 
• 120640-48-4 (2R)-2r-(3,4-dimethoxy-phenyl)-5,7-dimethoxy-3c-(toluene-4-sulfonyloxy)-chroman 
• 6953-67-9 1-(3,4-dimethoxyphenyl)prop-2-yn-1-ol 
• 34239-56-0 1-(3,4-dimethoxyphenyl)prop-2-yn-1-one 

Downstream Products

• 109396-03-4 1-(3,4-dimethoxy-phenyl)-2-hydroxy-3-(2-hydroxy-4,6-dimethoxy-phenyl)-propan-1-one 
• 102019-33-0 (3,4-dimethoxy-phenyl)-(2-hydroxy-4,6-dimethoxy-phenyl)-propanetrione 
• 102172-58-7 1-(3,4-dimethoxy-phenyl)-3-hydroxy-3-(2-hydroxy-4,6-dimethoxy-phenyl)-propane-1,2-dione 
• 10493-03-5 3',4',5,7-tetramethoxyflavylium chloride 
• 88186-80-5 2,3-cis-3-bromo-2,3',4',5,7-pentamethoxyflavan 
• 17060-21-8 3',4',5,7-tetramethoxyflavan 
• 88186-86-1 cis-3-bromo-3',4',5,7-tetramethoxyflavan 
• 95731-51-4 2,3-cis-3-bromo-3',4',5,7-tetramethoxy-2-(2,3-trans-3',4',5,7-tetramethoxyflavan-3-yloxy)flavan 
• 95731-51-4 2,3-cis-3-bromo-3',4',5,7-tetramethoxy-2-(2,3-trans-3',4',5,7-tetramethoxyflavan-3-yloxy)flavan 
• 94143-69-8 2-acetoxy-3',4,4',6-tetramethoxychalcone 
• 103650-43-7 2-acetoxy-3-(2-acetoxy-4,6-dimethoxy-phenyl)-1-(3,4-dimethoxy-phenyl)-propan-1-one 

Relevant academic research and scientific papers

Bioactive Phytochemicals: Efficient Synthesis of Optically Active Substituted Flav-3-enes and Flav-3-en-3-o-R Derivatives

The structural core of flavene (2-phenyl-2H-chromene) is commonly found in plant flavonoids, which exhibit a wide range of biological activities and diverse pharmacological profiles (e.g., antioxidant and anticancer activities). Flavonoids have attracted significant interest in medicinal and synthetic chemistry. Substituted flav-3-ene 13 was exclusively synthesized by the stereoselective elimination of the O-mesyl moiety on C-3 of 5,7,3′,4′-tetramethoxyflavan-3-mesylate 12 with 1,8-diazabicyclo[5.4.0]undec-7-ene. The reaction of 5,7,3′,4′-tetramethoxyflavan-3-one 15 with ytterbium trifluoromethanesulfonate in methanol afforded a novel 3-O-substituted flav-3-ene derivative (3,5,7,3′,4′-pentamethoxyflav-3-ene) 17. The reduction of 4-(1,3,5-trihydroxybenzene)-5,7,3′,4′-tetra-O-benzylflavan-3-one 19b with hydrogen afforded a new compound: 3-hydroxy-4-(1,3,5-trihydroxybenzene)-5,7,3′,4′-tetrahydroxyflavan-3-en-3-ol 21 in good yield (95%), while the acetylation of 19a and 21 afforded the expected novel flav-3-en-3-acetoxy derivatives 20 (92%) and 22 (90%), respectively.