20054-45-9

Basic information

• Product Name: N-methyl-2-sulfanylbenzamide
• Synonyms: N-methyl-2-sulfanylbenzamide;BenzaMide, 2-Mercapto-N-Methyl-;2- Mercapto-N-MethyllbenzaMide;2-MERCAPTO-N-METHYL BENZAMIDE(RE-EXPORTWIDE B/E.NO:2513786 DT 08.09.2015)
• CAS NO: 20054-45-9
• Molecular Formula: C8H9NOS
• Molecular Weight: 167.231
• EINECS: 1592732-453-0
• Product Categories: Intermediate
• Mol File: 20054-45-9.mol
• Article Data: 13

Chemical Properties

• Melting Point: 94-96 °C
• Boiling Point: 326.2 °C at 760 mmHg
• Flash Point: 151.1 °C
• Appearance: /
• Density: 1.174
• Storage Temp.: 2-8°C
• PKA: 5.89±0.43(Predicted)
• CAS DataBase Reference: N-methyl-2-sulfanylbenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-methyl-2-sulfanylbenzamide(20054-45-9)
• EPA Substance Registry System: N-methyl-2-sulfanylbenzamide(20054-45-9)

Safety Data

• Hazardous Substances Data: 20054-45-9(Hazardous Substances Data)

Usage

Description

N-methyl-2-sulfanylbenzamide is an axitinib intermediate.

Uses

2-Mercapto-N-methyl-benzamide is an intermediate used to prepare axitinib (A794650) which is a tyrosine kinase inhibitor. Axitinib is used in cancer therapy.

Application

2-Mercapto-N-methyl-benzamide is an intermediate used to prepare axitinib which is a tyrosine kinase inhibitor. Axitinib is used in cancer therapy.

Upstream product

• 2527-66-4 2-methyl-1,2-benzisothiazole-3(2H)-one 
• 593-51-1 methylamine hydrochloride 
• 4892-02-8 Methyl thiosalicylate 
• 1862-88-0 N-methylsalicylamide 
• 16420-13-6 N,N-Dimethylthiocarbamoyl chloride 
• 147-93-3 Thiosalicylic acid 
• 1050884-48-4 2-(4-trifluoromethyl-benzylsulfanyl)-benzoic acid 
• 101093-83-8 2-(4-methoxy-benzylsulfanyl)-benzoic acid 
• 1531-80-2 2-(benzylthio)benzoic acid 
• 1315275-23-0 N-methyl-2-(4-methyl-1-phenylpentylsulfinyl)benzamide 
• 1315275-16-1 (S)-2-(benzylsulfinyl)-N-methylbenzamide 
• 872220-84-3 N-methyl-2-(4-(trifluoromethyl)benzylsulfinyl)benzamide 
• 872220-83-2 2-(4-methoxybenzylsulfinyl)-N-methylbenzamide 
• 119-80-2 2,2'-dithiobenzoic acid 

Downstream Products

• 343869-32-9 2-(N-methylcarbamoyl)phenyl 4-acetylphenyl sulfide 
• 343869-33-0 2-(N-methylcarbamoyl)phenyl 4-carboxy3henyl sulfide 
• 127905-49-1 2-(N-methylcarbamoyl)phenyl 2-methoxyphenyl sulfide 
• 135781-45-2 2-<2-(N-methylcarbamoyl)phenylthio>benzoic acid 
• 343869-27-2 2-(N-methylcarbamoyl)phenyl 4-methylphenyl sulfide 
• 343869-25-0 2-(N-methylcarbamoyl)phenyl 2-chlorophenyl sulfide 
• 127905-51-5 2-(N-methylcarbamoyl)phenyl 4-methoxyphenyl sulfide 
• 343869-31-8 2-(N-methylcarbamoyl)phenyl 4-(N-methycarbamoyl)phenyl sulfide 
• 944835-85-2 2-{(1H-indazol-6-yl)thio}-N-methylbenzamide 
• 854886-89-8 Hg(SC₆H₄CONHCH₃)2 
• 872220-83-2 2-(4-methoxybenzylsulfinyl)-N-methylbenzamide 
• 872220-84-3 N-methyl-2-(4-(trifluoromethyl)benzylsulfinyl)benzamide 
• 2527-66-4 2-methyl-1,2-benzisothiazole-3(2H)-one 
• 1315275-25-2 N-(4-methyl-1-phenylpentyl)acetamide 

Relevant articles and documents

Axitinib intermediate compound and preparation method thereof

The invention belongs to the field of pharmaceutical chemicals, and particularly relates to an axitinib intermediate compound and a preparation method thereof. The present invention provides a novel axitinib intermediate compound S-(2-(methylcarbamoyl) phenyl) dimethylthioformate, the invention also provides a preparation method thereof. The method comprises the following steps: dissolving 2-hydroxy-N-methylbenzamide in an organic solvent, and adding dimethylaminothioformyl chloride and a catalyst to obtain the S-(2-(methylcarbamoyl) phenyl) dimethylthioformate. The new intermediate compound can be used for preparing the axitinib important intermediate 2-sulfydryl-N-methylbenzamide, and the synthesis method provided by the invention is short in route, simple to operate and high in yield and purity of the obtained 2-sulfydryl-N-methylbenzamide, and is suitable for industrial production.

Safe, Scalable, Inexpensive, and Mild Nickel-Catalyzed Migita-Like C?S Cross-Couplings in Recyclable Water

A new approach to C?S couplings is reported that relies on nickel catalysis under mild conditions, enabled by micellar catalysis in recyclable water as the reaction medium. The protocol tolerates a wide range of heteroaromatic halides and thiols, including alkyl and heteroaryl thiols, leading to a variety of thioethers in good isolated yields. The method is scalable, results in low residual metal in the products, and is applicable to syntheses of targets in the pharmaceutical area. The procedure also features an associated low E Factor, suggesting a far more attractive entry than is otherwise currently available, especially those based on unsustainable loadings of Pd catalysts.

NOVEL ULK1 INHIBITORS AND METHODS USING SAME

In certain aspects, the invention provides a method for treating a disease or condition in a subject, the method comprising co-administering to a subject in need thereof a therapeutically effective amount of at least one ULK1-inhibiting pyrimidine, and a therapeutically effective amount of an mTOR inhibitor.